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SF 6847

Also Known As:

3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile; RG 50872; SF-6847; SF6847; malonoben; tyrphostin 9; tyrphostin AG17

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitriles: 227
  - SF 6847: 8

Experts

1.	Kandandapani, Salanee: 1 article (09/2020)
2.	Mohamad, Saharuddin B: 1 article (09/2020)
3.	Ridzwan, Nor Farrah Wahidah: 1 article (09/2020)
4.	Tayyab, Saad: 1 article (09/2020)
5.	Blondel, Danielle: 1 article (01/2019)
6.	Gaudin, Yves: 1 article (01/2019)
7.	Lagaudrière-Gesbert, Cécile: 1 article (01/2019)
8.	Lama, Zoé: 1 article (01/2019)
9.	Hori, Hitoshi: 1 article (07/2016)
10.	Kawaguchi, Yuki: 1 article (07/2016)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2020 - "Tyrphostin 9 (Tyr 9) is a potent platelet-derived growth factor receptor (PDGFR) inhibitor, which induces apoptosis in various cancer cell types. " 02/01/1996 - "This report also supports the notion that the inhibition of tumor cell growth of inhibitor of protein tyrosine kinase AG17, which is identical to SF 6847, may be due to its mitochondrial cytotoxicity." 07/01/2016 - "Tyrphostin AG17 was previously shown to be a potent tumor growth inhibitor, while AG17 induced apoptosis and inhibited activity of cyclin-dependent kinase 2. We herein describe the binding features of tyrphostin AG17 analogs, such as TX-1123, with Src kinase (Src-K). "
2.	Starvation 04/01/1996 - "Algae were analyzed during several days of sulfate starvation for nonphotochemical quenching of chlorophyll fluorescence in the absence or presence of the uncouplers SF-6847 (SF) or carbonyl cyanide p- trifluoromethoxyphenyl hydrazone. "
3.	Lymphoma (Lymphomas) 12/15/1997 - "Palumbo et al., the tyrphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2. "
4.	Infections 01/01/2019 - "After screening a library of 80 kinases inhibitors, we identified two compounds as potent inhibitors of RABV infection: tyrphostin 9 and rottlerin. "
5.	Hodgkin Disease (Hodgkin's Disease) 06/01/2005 - "STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis."

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase 2
2.	src-Family Kinases
3.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
4.	Sulfates (Sulfates, Inorganic)
5.	Protein-Tyrosine Kinases (Tyrosine Kinase)
6.	Phosphotransferases (Kinase)
7.	Hydrazones
8.	Growth Inhibitors
9.	Chlorophyll
10.	2- hydroxyarylidene- 4- cyclopentene- 1,3- dione