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isoharringtonine

alkaloid from Cephalotaxus harringtonia

Also Known As:

4-methylcephalotaxine 2,3-dihydroxy-2-(3-methylbutyl)butanedioate ester

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Harringtonines: 5
    - isoharringtonine: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Harringtonines: 5
        isoharringtonine: 6
  - 4 or More Rings Heterocyclic Compounds
    - Harringtonines: 5
      - isoharringtonine: 6

Experts

1.	Cho, Myoung-Lae: 1 article (11/2020)
2.	Hwang, Wonbin: 1 article (11/2020)
3.	Kim, Yong-Nyun: 1 article (11/2020)
4.	Lee, Ji Hae: 1 article (11/2020)
5.	Park, So-Young: 1 article (11/2020)
6.	Shim, Jaegal: 1 article (11/2020)
7.	Sung, Jee Young: 1 article (11/2020)
8.	Yoon, Kyungsil: 1 article (11/2020)
9.	Cai, Xianghai: 1 article (07/2018)
10.	Chen, Wei: 1 article (07/2018)

Related Diseases

1.	Leukemia 06/01/1998 - "[Isoharringtonine induces apoptosis in human leukemia HL-60 cell]." 10/01/1999 - "To study the effects of homoharringtonine and isoharringtonine on the induction of apoptosis on human promyelocytic leukemia HL-60 cells. " 01/01/1992 - "Harringtonine, homoharringtonine, deoxyharringtonine and isoharringtonine isolated from Cephalotaxus plant are the esters of cephalotaxine with significant inhibitory activity against P-388 leukemia. "
2.	Acute Promyelocytic Leukemia 10/01/1999 - "[Apoptosis inductive effect of homoharringtonine and isoharringtonine on human acute promyelocytic leukemia HL-60 cells]." 06/01/1998 - "The cell apoptosis induced by isoharringtonine was investigated in human acute promyelocytic leukemia HL-60 cells by agarose gel electrophoresis of DNA, flow cytometry and transmission electron microscopy. "
3.	Neoplasms (Cancer) 11/06/2020 - "Furthermore, treatment with combined isoharringtonine and iNR4A1 significantly inhibited multivulva formation in a Caenorhabditis elegans model and tumor development in a xenograft mouse model. " 11/06/2020 - "We observed that knockdown of NR4A1 dramatically increased isoharringtonine-induced cancer cell death in A549 tumorspheroids by activating the intrinsic apoptosis pathway. " 11/06/2020 - "Taken together, our data suggest that isoharringtonine is a potential natural product for treatment of non-small cell lung cancers, and inhibition of NR4A1 sensitizes cancer cells to anti-cancer treatment." 05/01/1986 - "[Effects of synthetic isoharringtonine on DNA, RNA, ATP, protein and nucleoprotein of transplanted tumor cells in mice]."
4.	Lung Neoplasms (Lung Cancer) 11/06/2020 - "Taken together, our data suggest that isoharringtonine is a potential natural product for treatment of non-small cell lung cancers, and inhibition of NR4A1 sensitizes cancer cells to anti-cancer treatment."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/06/2020 - "Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway."

Related Drugs and Biologics

1.	Homoharringtonine
2.	DNA (Deoxyribonucleic Acid)
3.	Sepharose (Agarose)
4.	RNA (Ribonucleic Acid)
5.	Proteins (Proteins, Gene)
6.	Nucleoproteins
7.	Esters
8.	Adenosine Triphosphate (ATP)
9.	harringtonin
10.	deoxyharringtonine