limonin

01/01/2022 - "Limonin, with bioactivities of anti-inflammation, anti-apoptosis and anti-oxidative stress, may be effective for skin flap survival. "
03/01/2014 - "Limonin exerts protective effects on liver toxicity associated with inflammation and tissue injury via attenuation of inflammation and reduction of oxidative stress. "
09/01/2023 - "In vitro experiments also unveiled that limonin could decrease inflammation and oxidative stress in LPS-induced BMDM in a concentration-dependent manner. "
09/01/2023 - "Meanwhile, limonin also markedly decreased inflammation and oxidative stress in lung tissues from LPS-treated mice. "
04/17/2023 - "Limonin suppresses inflammation in the nucleus pulposus in vitro by reducing the production of pro-inflammatory markers such as iNOS and COX-2. "

01/01/2021 - "Limonin modulated immune and inflammatory responses to suppress colorectal adenocarcinoma in mice model."
01/01/2000 - "In a subsequent long-term experiment (38 weeks), in which rats were initiated with AOM and fed 0.05% obacunone or 0.05% limonin during the initiation or post-initiation phase, both compounds in diet caused significant reduction (65%-92% inhibition) in the incidence of colonic adenocarcinoma. "
01/01/2001 - "Obacunone or limonin feeding during the post-initiation phase also reduced the frequency of colonic adenocarcinoma (72 versus 13%, P = 0.0002). "
01/01/2001 - "At the termination of the study, dietary exposure to obacunone or limonin during the initiation phase was found to have significantly reduced the incidence of colonic adenocarcinoma (72 versus 25 or 6%, P = 0.004 or 0.00003). "

04/01/2021 - "Limonin is an important bioactive substance in citrus fruits, especially in seeds, which has great potential in cancer prevention and treatment. "
08/01/2020 - "The suppressive roles of limonin have been established in various tumors. "
09/01/2019 - "The inhibitory roles of limonin have been revealed in various tumors. "
04/01/2019 - "Limonin has been shown to exert anti-inflammatory effects, however, its roles in tumor progression remain unclear. "
01/01/1992 - "Multiple tumors were common in the animals treated with DMBA; however, the animals treated with limonin 17-beta-D-glucopyranoside exhibited a 55% decrease in average tumor burden. "

06/01/2006 - "These results suggest that consumption of grapefruit or limonin may help to suppress colon cancer development."
03/23/2011 - "The current study was an attempt to elucidate the mechanism of human colon cancer cell proliferation inhibition by limonin and limonin glucoside (LG) isolated from seeds of Citrus reticulata. "
03/23/2011 - "Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis."
07/01/2015 - "We finally confirmed the effects of limonin on β-catenin signaling, and found limonin significantly inhibited T-cell factor/lymphocyte enhancer factor-dependent transcriptional activity in a dose-dependent manner in the Caco-2 human colon cancer cell line. "
01/01/2001 - "Our results suggest that the citrus limonoids obacunone and limonin might be useful for the prevention of human colon cancers."

01/01/2023 - "Limonin shows promise in alleviating non-alcoholic fatty liver disease. "
01/01/2022 - "Furthermore, the treatment of limonin induced AMPK mediated suppression of the transcriptional activity of SREBP1/2. Our study suggests that limonin may a promising therapeutic agent for the treatment of NAFLD."
01/01/2021 - "However, the potential molecular mechanism of limonin on NAFLD in zebrafish remains unknown. "
01/01/2021 - "In this study, zebrafish larvae were exposed to thioacetamide to establish an NAFLD model and the larvae were treated with limonin for 72 h simultaneously. "
01/01/2021 - "The results showed that Limonin significantly reduced the accumulation of lipid droplets in the liver and down-regulated the levels of lipogenic transcription factors FASN and SREBP1 in NAFLD. "