|1.||Patil, Bhimanagouda S: 5 articles (04/2013 - 01/2006)|
|2.||Jayaprakasha, G K: 3 articles (04/2013 - 03/2011)|
|3.||Mahmoud, Mona F: 2 articles (10/2014 - 03/2014)|
|4.||Chidambara Murthy, Kotamballi N: 2 articles (04/2013 - 03/2011)|
|5.||Tanaka, T: 2 articles (01/2001 - 01/2000)|
|6.||Miyake, M: 2 articles (01/2001 - 01/2000)|
|7.||Wada, K: 2 articles (01/2001 - 01/2000)|
|8.||Kohno, H: 2 articles (01/2001 - 01/2000)|
|9.||Sun, Hui: 1 article (11/2015)|
|10.||Wang, Huiyu: 1 article (11/2015)|
03/23/2011 - "Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis."
01/01/2000 - "In a subsequent long-term experiment (38 weeks), in which rats were initiated with AOM and fed 0.05% obacunone or 0.05% limonin during the initiation or post-initiation phase, both compounds in diet caused significant reduction (65%-92% inhibition) in the incidence of colonic adenocarcinoma. "
01/01/2001 - "Obacunone or limonin feeding during the post-initiation phase also reduced the frequency of colonic adenocarcinoma (72 versus 13%, P = 0.0002). "
01/01/2001 - "At the termination of the study, dietary exposure to obacunone or limonin during the initiation phase was found to have significantly reduced the incidence of colonic adenocarcinoma (72 versus 25 or 6%, P = 0.004 or 0.00003). "
|2.||Colonic Neoplasms (Colon Cancer)
06/01/2006 - "These results suggest that consumption of grapefruit or limonin may help to suppress colon cancer development."
03/23/2011 - "The current study was an attempt to elucidate the mechanism of human colon cancer cell proliferation inhibition by limonin and limonin glucoside (LG) isolated from seeds of Citrus reticulata. "
07/01/2015 - "We finally confirmed the effects of limonin on β-catenin signaling, and found limonin significantly inhibited T-cell factor/lymphocyte enhancer factor-dependent transcriptional activity in a dose-dependent manner in the Caco-2 human colon cancer cell line. "
04/30/2013 - "In the current study, we examined the ability of limonoids, including limonin, limonin glucoside (LG) and curcumin, to inhibit proliferation of human colon cancer (SW480) cells. "
01/01/2001 - "Our results suggest that the citrus limonoids obacunone and limonin might be useful for the prevention of human colon cancers."
10/05/2014 - "The current study aimed to investigate the protective effects of limonin on experimentally-induced hepatic ischemia reperfusion (I/R) injury in rats. "
10/05/2014 - "Rats were injected IP with either DMSO or limonin (100 mg/kg BW), 30 min before submission to 45 min of ischemia, followed by 1 h of reperfusion. "
10/05/2014 - "Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway."
03/01/2014 - "Limonin exerts protective effects on liver toxicity associated with inflammation and tissue injury via attenuation of inflammation and reduction of oxidative stress. "
01/01/2015 - "Limonin, one of the major components in dictamni radicis cortex (DRC), has been shown to play various biological roles in cancer, inflammation, and obesity in many different cell types and tissues. "
03/01/2014 - "Oral administration of limonin before D-GalN injection, significantly attenuated markers of hepatic damage (elevated liver enzyme activities and total bilirubin) and hepatic inflammation (TNF-α, infiltration of neutrophils), oxidative stress and expression of TLR-4 but not TLR-2 in D-GalN-treated rats. "
03/01/2014 - "We have investigated the effects of limonin isolated from the dichloromethane fraction of the seeds of bittersweet orange (Citrus aurantium var. bigaradia) in two dose levels (50 and 100 mg/kg) against D-galactosamine (D-GalN)-induced liver toxicity in comparison with standard silymarin treatment on Toll-like receptors expression and hepatic injury, using a well-established rat model of acute hepatic inflammation. "
|5.||Breast Neoplasms (Breast Cancer)
01/01/2012 - "Citrus limonin lacks the antichemotherapeutic effect in human models of breast cancer."
01/01/2012 - "Both in vitro and in vivo results suggest that limonin could be beneficial for breast cancer patients undergoing chemotherapy."
01/01/2012 - "Our results indicate that limonin did not inhibit camptothecin-induced apoptosis in human breast cancer cells in vitro through noninterference of camptothecin-induced phosphorylation of p38 MAPK and ERK-MAPK. "
01/01/2012 - "Breast cancer cell lines MCF-7 (p53 wild type) and MDA-MB-231 (p53 mutant) as well as the nontumorigenic epithelial cell line MCF-10 were used to screen the effect of limonin at 1-, 5- and 10-µM concentrations with camptothecin for apoptosis and NFĸB, p38 and ERK-MAPK signaling kinase assays. "
01/01/2012 - "Using an in vivo model of human breast cancer, limonin in combination with cyclophosphamide was not found to inhibit the cyclophosphamide-induced tumor regression through a reduced mitotic index of tumor xenograft cells when compared to treatment with cyclophosphamide alone. "
|8.||ganoderic acid A
|1.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)
|4.||Chinese Traditional Medicine (Traditional Chinese Medicine)