4-ipomeanol

12/01/1987 - "Preclinical toxicology studies of 4-ipomeanol: a novel candidate for clinical evaluation in lung cancer."
07/01/1986 - "The present studies indicate that the further preclinical testing and development of 4-ipomeanol is warranted, with a view toward possible clinical evaluation against human lung cancers."
04/15/1993 - "Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans."
08/02/1989 - "4-Ipomeanol (IPO) is the first agent to undergo preclinical development at the National Cancer Institute (NCI) based principally on a specific biochemical-biological rationale for clinical investigation as an antineoplastic agent targeted against lung cancer. "
08/02/1989 - "4-Ipomeanol: a novel investigational new drug for lung cancer."

10/01/2003 - "Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol."
11/01/1982 - "Whole body plethysmography as a noninvasive assay of toxic lung injury in mice: studies with the pulmonary alkylating agent and cytotoxin, 4-ipomeanol."
11/01/2002 - "The importance of cytochrome P450 monooxygenase dependent metabolism in chemical-induced lung injury in animal models was established over 25 years ago with the furan, 4-ipomeanol. "

02/01/1987 - "The effects of the pulmonary toxicant, 4-ipomeanol (4-IP), on Sendai viral pneumonia was examined in young adult female C57BL/6J mice. "
09/01/1991 - "The objectives of this study were to determine whether calves are susceptible to 4-ipomeanol-induced enhancement of parainfluenza type 3 viral pneumonia and to determine whether 4-ipomeanol alters pulmonary replication of parainfluenza virus. "

09/01/1998 - "Phase I study of a five-day dose schedule of 4-Ipomeanol in patients with non-small cell lung cancer."
07/01/1986 - "Metabolic activation and cytotoxicity of 4-ipomeanol in human non-small cell lung cancer lines."

09/01/1991 - "The objectives of this study were to determine whether calves are susceptible to 4-ipomeanol-induced enhancement of parainfluenza type 3 viral pneumonia and to determine whether 4-ipomeanol alters pulmonary replication of parainfluenza virus. "
09/01/1991 - "The results indicate that 4-ipomeanol exacerbates interstitial pneumonia in calves induced by bovine parainfluenza type 3 virus."
09/01/1991 - "Effects of 4-ipomeanol on bovine parainfluenza type 3 virus-induced pneumonia in calves."
09/01/1991 - "Male Holstein calves were injected with either 4-ipomeanol (3 mg/kg) or vehicle (polyethylene glycol) 3 days prior to intratracheal inoculation with either parainfluenza virus or sham inoculum of culture medium. "