hexachlorobutadiene

12/01/2003 - "Hexachlorobutadiene (HCBD) is a potent nephrotoxin in rodents that can cause degeneration, necrosis and regeneration in renal tubular epithelial cells. "
06/01/1995 - "After identical doses of hexachlorobutadiene, the extent of necrosis to the pars recta of the proximal tubules was increased in male rats compared to the necrotic changes in female rats. "
04/01/1989 - "This localization is coincident with the site-specific kidney necrosis produced by hexachloro-1,3-butadiene (HCBD). "
01/01/1996 - "The polychlorinated olefin hexachlorobutadiene and other haloolefins cause necrosis of the S-3 segment of the proximal tubules; their nephrotoxicity is dependent on bioactivation reactions. "
07/01/1985 - "In sheep with renal tubular necrosis and hepatocellular necrosis caused by dosage with hexachlorobutadiene, both enzymes were released into the plasma, and GGT, but not 5'-NT activity was found in urine. "

05/01/1998 - "Effect of hexachloro-1,3-butadiene on renal carcinogenesis in male rats pretreated with N-ethyl-N-hydroxyethylnitrosamine."

03/01/1967 - "[The effect of small doses of hexachlorobutadiene on central nervous activity and morphological changes in the animal organism in hexachlorbutadiene poisoning]."

02/01/2001 - "We studied the response of urinary protein overload on preexisting tubulointerstitial nephritis (TIN), which was induced in male Sprague Dawley rats by hexachloro-1,3-butadiene (HCBD). "

11/01/1978 - "Hexachlorobutadiene induced in situ cutaneous necrosis and its absorption induced systemic damage (fatty liver degeneration and epithelial necrotizing nephritis). "