|1.||Stuppner, H: 2 articles (08/2001 - 08/2001)|
|2.||Vollmar, A M: 2 articles (08/2001 - 08/2001)|
|3.||Dirsch, V M: 2 articles (08/2001 - 08/2001)|
|4.||Wu, Xiaoyan: 1 article (06/2014)|
|5.||Lu, Zhongpeng: 1 article (06/2014)|
|6.||Huang, Quanfang: 1 article (06/2014)|
|7.||Tan, Shimei: 1 article (06/2014)|
|8.||Liang, Shuang: 1 article (06/2014)|
|9.||Lin, Xing: 1 article (06/2014)|
|10.||Tian, Yuanchun: 1 article (06/2014)|
03/01/1985 - "A series of analogues related to helenalin demonstrated moderate capability for inhibiting the growth of murine P-388 lymphocytic leukemia cells in vivo and in vitro. "
02/01/1988 - "Although the parent sesquiterpene lactone, helenalin, and its derivative, bis(helenalinyl)malonate, are structurally related chemically, they demonstrate differences in their antineoplastic activity, with bis(helenalinyl)malonate being much more active against P-388 lymphocytic leukemia cell growth (T/C% = 261) compared with helenalin (T/C% = 162). "
03/01/1985 - "Antitumor agents 68: effects of a series of helenalin derivatives on P-388 lymphocytic leukemia nucleic acid and protein synthesis."
02/01/1988 - "Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo."
01/01/1988 - "Helenalin and bis (helenalinyl) malonate, sesquiterpene lactones, were shown to be cytotoxic against the growth of P-388 lymphocytic leukemia cells in culture. "
06/01/2014 - "In conclusion, helenalin had a significant protective effect on chronic ethanol-induced hepatic fibrosis and may be a major bioactive ingredient of C. "
06/01/2014 - "Helenalin attenuates alcohol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and suppressing HSC activation."
06/01/2014 - "The results revealed that helenalin significantly prevented alcohol-induced hepatic injury and fibrogenesis, as evidenced by the decrease in serum aminotransferase, the attenuation of histopathological changes, and the inhibition of the hepatic fibrosis indicators, such as hyaluronic acid, type III precollagen, laminin, hydroxyproline and collagen α type I. Mechanistically, studies showed that helenalin expedited ethanol metabolism by enhancing the alcohol and aldehyde dehydrogenase activities. "
01/01/1994 - "Studies with saponin-permeabilized HT-29 human colon carcinosarcoma cells indicated that helenalin caused an increased accumulation of Ca2+ into nonmitochondrial stores and that the potentiating effect of helenalin on mitogen-stimulated [Ca2+]i responses was due in part to an increase in the inositol-(1,4,5)-trisphosphate-mediated release of Ca2+ from these stores."
03/01/2013 - "Helenalin, a sesquiterpene lactone, exhibits anti-inflammatory and anti-tumor activities. "
01/01/2013 - "Helenalin, with a hydrophobic structure obtained from flowers of Arnica chamissonis and Arnica Montana, has anti-cancer and anti-inflammatory activity but low water solubility and bioavailability. "
01/01/2012 - "Taken together, these results show that helenalin mediated autophagic cell death entails inhibition of NF-κB p65, thus providing a promising approach for the treatment of cancers with aberrant activation of the NF-κB pathway."
01/01/2012 - "To deduce the mechanistic action of helenalin, cancer cells were treated with the drug at various concentrations and time intervals. "
12/01/1989 - "After three days treatment of mice with helenalin, GSH levels were reduced and NPS levels elevated in P-388 tumor cells. "
03/28/2005 - "In this report, we investigated the effect of helenalin on cellular differentiation in the human promyelocytic leukemia HL-60 cell culture system. "
03/28/2005 - "Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone."
08/01/2001 - "We show here that the sesquiterpene lactone helenalin (10-50 microM) induces apoptosis in leukemia Jurkat T cells even if they lack the CD95 death receptor or overexpress the antiapoptotic proteins Bcl-x(L) or Bcl-2. "
08/01/2001 - "Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induce apoptosis in Jurkat leukemia T cells as judged by cell morphology, the appearance of apoptotic nuclei as well as the translocation of phosphatidylserine to the outer surface of the cell membrane."
02/01/1992 - "Naturally occurring sesquiterpene lactones and their semisynthetic derivatives, such as the O = C-C = CH-bearing helenalin and its esters, have been shown to demonstrate potent cytotoxicity against the growth of murine L1210 lymphoid leukemia and human Tmolt3 leukemia, colon adenocarcinoma, HeLaS3, lung bronchogenic, KB, osteosarcoma, and glioma cells. "
|1.||Glycyrrhetinic Acid (Po 12)
|7.||Hydroxyproline (4 Hydroxyproline)
|8.||Hyaluronic Acid (Hyaluronan)
|10.||Ethanol (Ethyl Alcohol)