guanidinosuccinic acid

09/01/1970 - "Further studies on the platelet-inhibitory effect of guanidinosuccinic acid and its role in uremic bleeding."

02/15/2005 - "Guanidinosuccinic acid (GSA) is an important probable uremic toxin, increased in plasma, urine, cerebrospinal fluid and brain of patients with uremia and supposed to play a role in the pathogenesis of some neurological symptoms. "
12/01/1992 - "Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. "
07/01/1974 - "[Experimental changes in myocardial contractility produced by a toxic substance retained in uremia: guanidinosuccinic acid]."
10/01/1971 - "[Guanidinosuccinic acid and uremia. "
03/15/1971 - "[Guanidinosuccinic acid and uremia. "

04/01/2007 - "Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. "
09/01/1995 - "Accumulation of guanidinosuccinic acid increased with increasing degree of renal failure with levels up to 65 nmol/g tissue in the hypophysis. "
02/01/1995 - "(3) After induction of renal failure, Arg, creatine and guanidinosuccinic acid reabsorption remained unchanged, and that of HArg decreased. "
04/24/1969 - "Guanidinosuccinic acid in renal failure, experimental azotemia and inborn errors of the urea cycle."
12/01/2001 - "As in human renal insufficiency, NX mice showed significantly higher plasma guanidinosuccinic acid (GSA) and creatinine (CTN) levels at all studied periods. "

02/01/1983 - "[Hyperprolactinemia and guanidinosuccinic acid in chronic renal failure]."
01/01/1996 - "In 37 end stage renal disease (ESRD) pts the electroneurophysiological (ENF) parameters and serum creatinine (Pcr), guanidino compounds (GC) and guanidinosuccinic acid (GSA) levels were studied. "
02/04/1991 - "Activity of methemoglobin reductase was studied in human red cells treated with methylguanidine and guanidinosuccinic acid in concentrations similar to those in plasma of patients with chronic renal failure. "
01/01/1981 - "o-Hydroxyphenolic acid and guanidinosuccinic acid, which were supposed to interfere with platelet function, inhibited glucose utilization at concentrations found in plasma of patients with chronic renal failure (CRF). "
01/01/1979 - "Effect of low protein diet and surplus of essential amino acids on the serum concentration and the urinary excretion of methylguanidine and guanidinosuccinic acid in chronic renal failure."

10/01/1991 - "Our results suggest that guanidinosuccinic acid and alpha-N-acetylarginine may play an important role in hyperammonemia."
02/01/1993 - "Blood and tissue guanidinosuccinic acid levels were not elevated during urease induced hyperammonemia, supporting the hypothesis that urea is a precursor for the synthesis of guanidinosuccinic acid."