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6-fluorotryptophan

an inhibitor of serotonin synthesis; RN given refers to parent cpd without isomeric designation

Also Known As:

6-fluorotryptophan, (DL)-isomer; 6-fluorotryptophan, (L)-isomer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Tryptophan: 6733
      - 6-fluorotryptophan: 2
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Tryptophan: 6733
        6-fluorotryptophan: 2

Related Diseases

1.	Melanoma (Melanoma, Malignant) 03/01/1978 - "Phenylalanine hydroxylase activity in melanoma cell extracts was identified by its inhibition with p-chlorophenylalanine and not with 6-fluorotryptophan, 3-iodotyrosine, phenylthiourea, tyrosine or tryptophan; and by adsorption with antiserum prepared against purified rat liver phenylalanine hydroxylase, and migration of immunoprecipitable activity with authentic phenylalanine hydroxylase subunits in sodium dodecyl sulfate-polyacrylamide gel electrophoresis."
2.	Hyperventilation 08/01/1979 - "In awake, unrestrained, intact rats, reserpine, para-chlorophenylalanine, 6-fluorotryptophan, and para-chloroamphetamine depleted whole brain serotonin and produced a substantial and sustained hyperventilation as evidenced by a 5--9 torr drop in PaCO2. "

Related Drugs and Biologics

1.	Fenclonine (p-Chlorophenylalanine)
2.	Tyrosine (L-Tyrosine)
3.	Tryptophan (L-Tryptophan)
4.	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)
5.	Serotonin (5 Hydroxytryptamine)
6.	Reserpine (Serpasil)
7.	Phenylthiourea (Phenylthiocarbamide)
8.	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)
9.	p-Chloroamphetamine
10.	Cell Extracts