febrifugine

05/20/2015 - "Febrifugine is the active principle of a traditional Chinese herbal remedy for malaria. "
02/07/2013 - "Moreover, our structure indicates a possible similar mechanism of action for febrifugine in malaria treatment. "
09/01/2010 - "As part of an ongoing malaria chemotherapy project, novel febrifugine analogues were designed and synthesized. "
02/07/2013 - "Febrifugine is the active component of the Chinese herb Chang Shan (Dichroa febrifuga Lour.), which has been used for treating malaria-induced fever for about 2,000 years. "
11/15/1999 - "These results indicate that the increased production of NO by febrifugine plays an important role in host defense against malaria infection in mice."

04/01/2023 - "Febrifugine and its derivatives possess extensive biological activities, some of which exhibited anti-tumor activities as FAK inhibitors. "
01/01/2017 - "To suppress the chemo- and radio-resistance of cancer cells caused by NRF2 accumulation, we conducted high-throughput chemical library screening for NRF2 inhibitors and identified febrifugine derivatives. "
02/07/2013 - "Halofuginone (HF), the halogenated derivative of febrifugine, has been tested in clinical trials for potential therapeutic applications in cancer and fibrotic disease. "
03/01/2022 - "Halofuginone (HL) is a less-toxic febrifugine derivative and has inhibitory effects on a variety of cancer cells. "
02/12/2012 - "Febrifugine derivatives have been used to treat malaria, cancer, fibrosis and inflammatory disease. "

02/12/2012 - "Febrifugine derivatives have been used to treat malaria, cancer, fibrosis and inflammatory disease. "
06/30/2021 - "Halofuginone, an analog of febrifugine, prevents fibrosis in various animal models, including those of muscular dystrophies. "
07/01/2019 - "Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various animal models, including those of muscular dystrophies. "
01/01/2022 - "Halofuginone has reduced toxic side effects when compared to febrifugine, an advantage that has led to the commercial availability of halofuginone-based antiparasitic drugs for animal use, and to human clinical trials for the treatment of tumors and fibrosis. "
12/01/2017 - "7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone (halofuginone), an analog of febrifugine, which specifically targets the pathogenesis of ECM proteins, inhibits tissue fibrosis and regeneration and even affects the development of tumors in various tissues. "

11/15/1999 - "Febrifugine significantly reduced the mortality and the level of parasitemia. "
06/01/2003 - "All mice treated with the fraction containing febrifugine and isofebrifugine mixture at 1 mg/kg twice a day for 5 consecutive days survived during the experiment, and the change of mean parasitemia level showed almost the same pattern as that from mice treated with the hot-water extract of the same plant leaves. "
11/01/2008 - "Parasitemia patterns, survival and cytokine levels of Plasmodium berghei NK65-infected BALB/c mice, treated orally with the alkaloidal mixture of febrifugine and isofebrifugine at a dose of 1 mg/kg twice a day for 4 consecutive days were monitored. "
12/01/2003 - "A four-day dosage of 1 mg/kg of the febrifugine and isofebrifugine mixture alone showed a little antimalarial activity, but all mice died from day 19 to 27 with an increasing parasitemia. "

05/01/2022 - "Febrifugine dihydrochloride as a new oral chemotherapeutic agent against visceral leishmaniasis infection."
11/15/1999 - "These results indicate that the increased production of NO by febrifugine plays an important role in host defense against malaria infection in mice."
10/01/2004 - "Cytokine and antibody production was investigated during the course of resolution of primary infection in Plasmodium yoelii 17XL-infected BALB/c mice treated with a mixture of febrifugine and isofebrifugine. "
12/01/2003 - "The combination effects of chloroquine with a mixture of febrifugine and isofebrifugine were evaluated against a blood-induced infection with chloroquine-resistant P. "
12/01/2003 - "Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice."