|1.||Kikuchi, Haruhisa: 3 articles (12/2014 - 06/2002)|
|2.||Oshima, Yoshiteru: 3 articles (12/2014 - 06/2002)|
|3.||Ishih, Akira: 3 articles (11/2008 - 06/2003)|
|4.||Miyase, Toshio: 3 articles (11/2008 - 06/2003)|
|5.||Mazitschek, Ralph: 2 articles (05/2015 - 03/2012)|
|6.||Cortese, Joseph F: 2 articles (05/2015 - 03/2012)|
|7.||Zhou, Huihao: 2 articles (05/2015 - 02/2013)|
|8.||Whitman, Malcolm: 2 articles (05/2015 - 03/2012)|
|9.||Schimmel, Paul: 2 articles (05/2015 - 02/2013)|
|10.||Wirth, Dyann F: 2 articles (05/2015 - 03/2012)|
05/20/2015 - "Febrifugine is the active principle of a traditional Chinese herbal remedy for malaria. "
02/07/2013 - "Moreover, our structure indicates a possible similar mechanism of action for febrifugine in malaria treatment. "
09/25/2003 - "Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite."
06/06/2002 - "Potent antimalarial febrifugine analogues against the plasmodium malaria parasite."
08/12/1999 - "New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite."
11/15/1999 - "Febrifugine significantly reduced the mortality and the level of parasitemia. "
11/01/2008 - "Parasitemia patterns, survival and cytokine levels of Plasmodium berghei NK65-infected BALB/c mice, treated orally with the alkaloidal mixture of febrifugine and isofebrifugine at a dose of 1 mg/kg twice a day for 4 consecutive days were monitored. "
12/01/2003 - "A four-day dosage of 1 mg/kg of the febrifugine and isofebrifugine mixture alone showed a little antimalarial activity, but all mice died from day 19 to 27 with an increasing parasitemia. "
06/01/2003 - "All mice treated with the fraction containing febrifugine and isofebrifugine mixture at 1 mg/kg twice a day for 5 consecutive days survived during the experiment, and the change of mean parasitemia level showed almost the same pattern as that from mice treated with the hot-water extract of the same plant leaves. "
11/15/1999 - "The plasma NO3- concentration began to rise within 2 days after treatment with febrifugine and declined to normal in 2 days when the mice were treated orally with febrifugine once a day for 3 consecutive days before parasite infection. "
11/15/1999 - "These results indicate that the increased production of NO by febrifugine plays an important role in host defense against malaria infection in mice."
10/01/2004 - "Cytokine and antibody production was investigated during the course of resolution of primary infection in Plasmodium yoelii 17XL-infected BALB/c mice treated with a mixture of febrifugine and isofebrifugine. "
12/01/2003 - "The combination effects of chloroquine with a mixture of febrifugine and isofebrifugine were evaluated against a blood-induced infection with chloroquine-resistant P. "
12/01/2003 - "Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice."
|3.||prolyl T RNA synthetase
|5.||Folic Acid Antagonists
|8.||Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
|10.||1-deoxy-D-xylulose 5-phosphate reductoisomerase
|1.||Drug Therapy (Chemotherapy)