dopachrome

10/01/2001 - "In this study we describe the purification and molecular cloning of a dopachrome conversion enzyme (DCE) from the yellow fever mosquito, Aedes aegypti. "
10/01/2001 - "Cloning and characterization of a dopachrome conversion enzyme from the yellow fever mosquito, Aedes aegypti."

05/01/1985 - "Using a purified preparation from hamster melanoma, the assay was found to be more sensitive than the commonly used dopachrome assay. "
09/14/1990 - "A protein that catalyzes the decoloration of dopachrome has been partially purified from B16 mouse melanoma tumors. "
01/01/2023 - "Knockdown (KD) of MGST1 depleted midline-localized, pigmented melanocytes in zebrafish embryos, while in both mouse and human melanoma cells, loss of MGST1 resulted in a catalytically dependent, quantitative, and linear depigmentation, associated with diminished conversion of L-dopa to dopachrome (eumelanin precursor). "
12/15/1993 - "Another enzyme that tautomerizes D-dopachrome with concomitant decarboxylation to give 5,6-dihydroxyindole (DHI) was found in the cytoplasm of human melanoma cells, human liver and in all of the organs studied in rat. "
01/01/1982 - "A suspended homogenate of cloned, cultured B16 mouse melanoma cells also showed peroxidatic conversion of tyrosine to dopachrome in the presence of dihydroxyfumarate co-factor. "

01/01/2005 - "Aluminum ions can greatly catalyze the conversion reaction of dopachrome to form 5,6-dihydroxyindole, which is a key step in the biosynthesis of melanin. "
01/01/2021 - "Melanin synthesis starts via the hydroxylation of L-tyrosine to L-3,4-Dihydroxyphenylalanine (DOPA) catalyzed by the enzyme known as Tyrosinase (TYR), which triggers further conversion reaction to DOPAquinone and then to DOPAchrome. "

01/13/2021 - "In the future, Tyr-MB could be used for large-scale productions of dopachrome and melanin-related products and finding a treatment for oculocutaneous albinism-inherited diseases."

07/01/2022 - "Ba significantly increased the expression of cathepsin B by 1.51-fold and downregulated the expression of D-dopachrome decarboxylase and pre-B-cell leukemia transcription factor-interacting protein 1 with a fold-change of 0.58 and 0.40, respectively. "