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6,6'-dithiodinicotinic acid
RN given refers to parent cpd; structure
Also Known As:
6,6'-dithiodinicotinic acid, sodium salt; carboxypyridine disulfide; 6,6'-dithiobis-3-pyridinecarboxylic acid
Networked:
8
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Nicotinic Acids: 13
6,6'-dithiodinicotinic acid: 8
Heterocyclic Acids
Nicotinic Acids: 13
6,6'-dithiodinicotinic acid: 8
Related Diseases
1.
Neoplasms (Cancer)
05/15/1986 - "
Cell surface binding studies with the non-penetrating disulfide, 6,6'-dithiodinicotinic acid, indicated that both tumors isolated from the liver had a greater than 5-fold elevation in surface sulfhydryls when compared to their ascitic counterparts.
"
2.
Ehrlich Tumor Carcinoma
05/01/1970 - "
Modification of external sulfhydryl groups of Ehrlich ascites tumor cells with 6,6'-dithiodinicotinic acid.
"
03/01/1969 - "
The interaction of 6,6'-dithiodinicotinic acid with thiols and with ehrlich ascites tumor cells.
"
03/01/1989 - "
In experiments with Ehrlich ascites tumor cells with the use of a specific thiol blocker, 6,6'-dithiodinicotinic acid, it was shown that thiols of a cell plasmic membrane are necessary for the radioprotective effect of mercaptoethylamine to be realized.
"
05/01/1988 - "
In experiments with Ehrlich ascites tumor cells, using a specific thiol blocker, 6,6'-dithiodinicotinic acid, that does not penetrate the cell and therefore only binds SH-groups of peripheral areas of an external cell membrane, it was demonstrated that (1) the external cell membrane is the site where the radioprotective effect of anoxia (the oxygen effect) is realised (2) thiols of the external cell membrane contribute markedly to the oxygen effect, and (3) they are needed at both stages of its realization.
"
3.
Yoshida Sarcoma
12/01/1972 - "
Chemical modification of cell membrane of Yoshida sarcoma cells by 6,6'-dithiodinicotinic acid and its effect on sensitivity to nitrogen mustard.
"
4.
Experimental Melanoma
08/01/1986 - "
We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo highly metastatic subline of murine B16 melanoma (F10).
"
5.
Melanoma (Melanoma, Malignant)
08/01/1986 - "
Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).
"
Related Drugs and Biologics
1.
Disulfides
2.
Sulfhydryl Compounds (Thiols)
3.
Oxygen (Dioxygen)
4.
Mechlorethamine (Nitrogen Mustard)
5.
Cysteamine (Mercaptamine)
6.
6-mercaptonicotinic acid