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dimethoxane

Also Known As:

6-acetoxy-2,4-dimethyl-m-dioxane

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxanes
    - dimethoxane: 2

Related Diseases

1.	Carcinogenesis 09/01/1989 - "NTP Toxicology and Carcinogenesis Studies of Dimethoxane (CAS No. 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)." 09/01/1989 - "Toxicology and carcinogenesis studies were conducted by administering commercial-grade dimethoxane (80% pure, none of these impurities exceeded 3%) in corn oil gavage to groups of F344/N rats and B6C3F1 mice of each sex one time or 5 days per week for 16 days, 13 weeks, 15 months, or 2 years. "
2.	Inflammation (Inflammations) 09/01/1989 - "Lesions of the forestomach, including inflammation, hyperplasia, hyperkeratosis, and ulceration, occurred in rats that received 250-2,000 mg/kg. Mice that received 500-2,000 mg/kg dimethoxane had lesions of the forestomach including erosion, ulceration, hyperplasia, and hyperkeratosis. " 09/01/1989 - "Ulceration, inflammation, and acanthosis with hyperkeratosis of the stratified squamous epithelium of the forestomach were seen in rats that received 500 mg/kg. Forestomach lesions were not seen in males that received 31 mg/kg or in females that received 31, 62, or 125 mg/kg. All mice lived to the end of the studies (doses used were 0, 31, 62, 125, 250, or 500 mg/kg dimethoxane in corn oil by gavage). "
3.	Body Weight (Weight, Body) 09/01/1989 - "Because of the forestomach lesions observed in rats and mice and reduced body weight observed for male rats, doses selected for the 2-year studies were 0, 62.5, or 125 mg/kg dimethoxane in corn oil, given by gavage 5 days per week to groups of 60 male rats; 0, 125, or 250 mg/kg to groups of 60 female rats; and 0, 250, or 500 mg/kg to groups of 58 or 60 mice of each sex. "
4.	Allergic Contact Dermatitis 10/01/1980 - "A textile worker exposed to dimethoxane in an aqueous system developed allergic contact dermatitis. " 10/01/1980 - "Allergic contact dermatitis to dimethoxane in a spin finish."
5.	Papilloma (Papillomatosis) 09/01/1989 - "Other than a single squamous cell papilloma in the esophagus of a low dose male mouse, no hyperplastic or neoplastic lesions were seen outside the stomach of dosed mice which could be related to the administration of dimethoxane. "

Related Drugs and Biologics

1.	Corn Oil (Oil, Corn)