|1.||Gieseg, Steven P: 4 articles (11/2010 - 09/2005)|
|2.||Goulding, Celia W: 2 articles (06/2014 - 05/2005)|
|3.||Baird, Sarah K: 2 articles (09/2008 - 09/2005)|
|4.||Firth, Carole A: 2 articles (09/2008 - 06/2008)|
|5.||Wirleitner, B: 2 articles (11/2000 - 01/2000)|
|6.||Fuchs, D: 2 articles (11/2000 - 01/2000)|
|7.||Widner, B: 2 articles (11/2000 - 01/2000)|
|8.||Fitzpatrick, James A J: 1 article (06/2014)|
|9.||Joens, Matthew S: 1 article (06/2014)|
|10.||Contreras, Heidi: 1 article (06/2014)|
11/01/2000 - "Inflammation marker 7,8-dihydroneopterin induces apoptosis of neurons and glial cells: a potential contribution to neurodegenerative processes."
09/01/2008 - "The concentration of total neopterin suggests that 7,8-dihydroneopterin could act as an antioxidant during inflammation."
02/01/2008 - "This has led to the suggestion that 7,8-dihydroneopterin is synthesized to protect macrophages from the oxidants released during inflammation. "
08/19/2002 - "The possibility that 7,8-dihydroneopterin is a cellular antioxidant protecting macrophage proteins during inflammation is discussed."
06/01/2008 - "In addition to producing various oxidants, human macrophages release 7,8-dihydroneopterin which in vivo is oxidised to the inflammation marker neopterin. "
|2.||Atherosclerotic Plaque (Atheroma)
06/01/2008 - "This suggests that 7,8-dihydroneopterin synthesis by macrophages could play a significant role in the development of atherosclerotic plaques."
11/15/2010 - "The severity of atheroma burden in patients strongly correlates to increasing levels of plasma neopterin, the oxidation product of 7,8-dihydroneopterin. "
09/30/2005 - "The data show that muM levels of 7,8-dihydroneopterin may prevent oxLDL mediated cellular death within atherosclerotic plaques."
06/01/2008 - "Although stimulation of both cell types with gamma-interferon failed to produce sufficient 7,8-dihydroneopterin to inhibit LDL oxidation in tissue culture, analysis of advanced atherosclerotic plaque removed from patients showed that total neopterin levels could reach low micromolar concentrations. "
02/01/2008 - "Plasma neopterin originates as the oxidation product of 7,8-dihydroneopterin secreted by gamma-interferon stimulated macrophages within atherosclerotic plaques. "
05/12/1990 - "Increased 7,8-dihydroneopterin and reduced methyl-group metabolism in HIV-1 infection."
07/01/2002 - "In cerebrospinal fluid of patients with cerebral infections, elevated concentrations of the pteridine compounds neopterin and 7,8-dihydroneopterin were detected. "
10/01/1996 - "Role of neopterin and 7,8-dihydroneopterin in human immunodeficiency virus infection: marker for disease progression and pathogenic link."
06/27/2014 - "tuberculosis protein involved in folate biosynthesis, 7,8-dihydroneopterin aldolase (Mt-FolB), have C-terminal tails that could also interact with Mt-Enc. "
05/27/2005 - "We hypothesize that Mtb FolB displays cooperativity in substrate binding to regulate the cellular concentration of 7,8-dihydroneopterin, so that it may function not only as a precursor to folate but also as an antioxidant for the survival of M.tuberculosis against host defenses."
05/27/2005 - "M.tuberculosis 7,8-dihydroneopterin aldolase (Mtb FolB, DHNA) is the second enzyme in the folate biosynthetic pathway, which catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and glycoaldehyde. "
|5.||Neurodegenerative Diseases (Neurodegenerative Disease)
|2.||Oxidants (Oxidizing Agents)
|3.||Interferon-gamma (Interferon, gamma)
|4.||Hydrogen Peroxide (Hydroperoxide)
|5.||Fructose-Bisphosphate Aldolase (Aldolase)
|6.||Folic Acid (Vitamin M)
|7.||Fas Ligand Protein (Fas Ligand)
|8.||Proteins (Proteins, Gene)