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diazoxon

a pesticide; structure

Also Known As:

O,O-diethyl O-(2-isopropyl-4-methylpyrimid-6-yl)phosphate; diazinon-oxon

Networked: 10 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - diazoxon: 10

Experts

1.	Mackness, Bharti: 2 articles (03/2019 - 01/2019)
2.	Mackness, Mike: 2 articles (03/2019 - 01/2019)
3.	Flaskos, John: 2 articles (06/2014 - 04/2009)
4.	Hargreaves, Alan J: 2 articles (06/2014 - 04/2009)
5.	Harris, Wayne: 2 articles (06/2014 - 04/2009)
6.	Sachana, Magdalini: 2 articles (06/2014 - 04/2009)
7.	Sidiropoulou, Erasmia: 2 articles (06/2014 - 04/2009)
8.	Woldehiwet, Zerai: 2 articles (06/2014 - 04/2009)
9.	Flaskos, J: 2 articles (11/2011 - 12/2009)
10.	Hargreaves, A J: 2 articles (11/2011 - 12/2009)

Related Diseases

1.	Neuroblastoma 04/01/2009 - "Diazinon oxon affects the differentiation of mouse N2a neuroblastoma cells." 04/01/2009 - "The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. " 06/01/2014 - "This study aimed at assessing the effects of diazoxon (DZO), a major metabolite of the insecticide diazinon (DZ), on key cytoskeletal proteins in differentiating N2a neuroblastoma cells. " 11/01/2011 - "Previous work in our laboratory has shown that sub-lethal concentrations (1-10 μM) of chlorpyrifos (CPF), diazinon (DZ) and diazinon oxon (DZO) inhibit the outgrowth of axon-like neurites in differentiating mouse N2a neuroblastoma cells concomitant with altered levels and/or phosphorylation state of axonal cytoskeleton and growth-associated proteins. "
2.	Poisoning 11/01/1966 - "Bioassay and histochemical studies of the poisoning and recovery of house-flies (Musca domestica L.) treated with diazinon and diazoxon."
3.	Glioma (Gliomas) 12/01/2009 - "Diazinon oxon interferes with differentiation of rat C6 glioma cells." 12/01/2009 - "The purpose of this study was to evaluate the toxicity of diazinon oxon (DZO), a major in vivo metabolite of the organophosphate insecticide diazinon (DZ), on differentiating rat C6 glioma cells. "
4.	Astrocytoma (Pilocytic Astrocytoma) 11/15/2005 - "To substantiate and expand these observations, we carried out a series of in vitro studies utilizing fetal rat astrocytes and a human astrocytoma cell line, 1321N1 cells, to investigate the effect of the OPs CP, diazinon (DZ) and parathion (P), their oxygen analogs chlorpyrifos oxon (CPO), diazoxon (DZO) and paraoxon (PO), and their metabolites 3,5,6-trichloro-2-pyridinol (TCP), 2-isopropyl-6-methyl-4-pyrimidol (IMP) and para-nitrophenol (PNP), on cell proliferation. "
5.	Coronary Disease (Coronary Heart Disease) 03/01/2019 - "Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease." 01/01/2019 - "Corrigendum to "Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease" [Clinical Biochemistry 65 (2019) 21-23]." 01/01/2006 - "Using a two-substrate (paraoxon/diazoxon) activity method, we investigated the frequencies of PON1Q192R phenotypes in 261 middle-aged subjects: 156 patients with angiographically assessed coronary heart disease (CHD) and 105 CHD-free subjects as the control group. "

Related Drugs and Biologics

1.	Diazinon (Dimpylate)
2.	Insecticides
3.	Paraoxon (E600)
4.	Organophosphates
5.	Parathion (Ethyl Parathion)
6.	Oxygen (Dioxygen)
7.	Nitrophenols
8.	Inosine Monophosphate (IMP)
9.	Cytoskeletal Proteins
10.	3,5,6-trichloro-2-pyridinol