E 25 (E-25)

E-25 referred to as HCl in Chemline; RN given refers to (1R-(1alpha,4abeta,10aalpha))-isomer

Also Known As:

E-25; (1R-(1 alpha,4a beta,10a alpha))-N-(2-(diethylamino)ethyl)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxamide; N-(diethylaminoethyl)dehydro-abietamide; N-(diethylaminoethyl)dehydroabietamide

Networked: 61 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Albanes, Demetrius: 2 articles (01/2017 - 11/2010)
2.	Mondul, Alison M: 2 articles (01/2017 - 11/2010)
3.	Weinstein, Stephanie J: 2 articles (01/2017 - 11/2010)
4.	Cavestro, Cinzia: 1 article (10/2022)
5.	Ferrero, Marcella: 1 article (10/2022)
6.	Fraire, Flavio: 1 article (10/2022)
7.	Genovesi, Corrado: 1 article (10/2022)
8.	Mandrino, Silvia: 1 article (10/2022)
9.	Manildo, Matteo: 1 article (10/2022)
10.	Martini, Sabina: 1 article (10/2022)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 02/01/2004 - "The EORTC trial 10951 randomised 122 postmenopausal breast cancer patients to exemestane (E) 25 mg (n = 62) or tamoxifen (T) 20 mg (n = 60) once daily as a first-line treatment in the metastatic setting. " 01/01/2020 - "The present review includes studies examining the association between endometriosis and different types of gynecological cancer (i.e., 25 studies on ovarian cancer, 8 studies on breast cancer, 8 studies on endometrial cancer and 2 studies on cervical cancer). "
2.	Weight Gain 01/15/2020 - "Nonetheless, the LbL treated fabric sample (i.e., PA66-10BL-UV) with a higher weight gain% exhibited a greater improvement in limiting oxygen index (LOI) (i.e., 23%), and a reduced peak heat release rate (pHRR) (i.e., 25%). "
3.	Ischemia 08/01/2007 - "The study included patients with intermediate lesions (i.e., 25-50%) in unprotected LMCAs, with no previous evidence of associated ischemia. " 03/01/1987 - "BAEP and SEP monitoring failed to identify ischemic events in 4 patients with neurological findings of brain stem ischemia immediately after operation (i.e., 25% false-negative studies).(ABSTRACT TRUNCATED AT 250 WORDS)"
4.	Neoplasms (Cancer) 02/01/2008 - "These sources (with Emax approximately few MeV) can be used for the treatment of tumors with a maximum diameter of about 1 cm. Low-energy X-rays (E<25 keV) can be used to extend the range of tumor diameter to 4-5 cm but require very tight biological vector characteristics." 02/01/2001 - "Twenty tumors were T1a, 26 T1b e 25 T1c. " 03/01/1987 - "Of 313 patients who had no change (i.e., +/- 25%) in the size of their tumors after hyperthermia, the response lasted only 1-3 months in 170 (54%) patients, a finding of questionable clinical significance. " 05/01/1999 - "Topical application of E-25 (500 mg/kg b.w./day) during peri-, post- or peri- and post-initiational stages of 7,12-dimethylbenz [a] anthracene (DMBA)-induced papillomagenesis, significantly modulated the a) tumor burden to 5.00, 4.33 and 3.94 (positive control value: 5.88 b) cumulative number of papillomas to 90, 78 and 67 (positive control value: 106); and c) percent incidence of mice bearing papillomas to 94, 90 and 89 respectively (positive control value: 100). " 01/01/2017 - "Higher circulating levels of vitamin D (i.e., 25-hydroxyvitamin D or 25(OH)D) appear to be associated with reduced risk of colorectal and bladder malignancies, but higher risk of prostate and possibly pancreatic cancers, with no clear association for most other organ sites examined. "
5.	Vitamin D Deficiency 01/01/2021 - "Results: Among 37,079 patients with CVD at baseline, 57.5% were subjected to vitamin D deficiency (i.e., 25[OH]D <50 nmol/L). " 12/01/2007 - "Vitamin D deficiency [i.e., 25(OH)D < 20 ng/ml] is common in both children and adults worldwide. " 10/01/2021 - "In the entire population, vitamin D deficiency (i.e., 25(OH)D values < 12 ng/mL) was significantly associated with acute hypoxemic respiratory failure at the study entry [adjusted odds ratio (OR) 2.48, 95% confidence interval 1.29-4.74; P = 0.006], independently of age and sex of subjects, serum calcium and inflammatory parameters. "

Related Drugs and Biologics

1.	Tamoxifen
2.	exemestane (Aromasin)
3.	Oxygen (Dioxygen)
4.	hydroxide ion
5.	Tablets
6.	Spironolactone (Aldactone)
7.	Potassium
8.	Hydrochlorothiazide (Esidrix)
9.	Doxorubicin (Adriamycin)
10.	Calcium

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy