securinine

a quinolizine pseudoalkaloid (not from amino acid) from Securinega suffurutiosa or Securinini nitras

Also Known As:

allonorsecurinine; allosecurinine; securinan-11-one; securinine methiodide; securinine nitrate; (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-methanofuro(2,3-c)pyrido(1,2-a)azepin-2(6H)-one

Networked: 34 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - securinine: 34
  - Azepines: 11
    - securinine: 34
- Bridged-Ring Heterocyclic Compounds
  - securinine: 34
Organic Chemicals: 133
- Lactones: 1549
  - securinine: 34

Experts

1.	Han, Shuwen: 3 articles (10/2017 - 03/2014)
2.	Ji, Zhaoning: 3 articles (10/2017 - 03/2014)
3.	Wang, Ying: 3 articles (05/2014 - 12/2011)
4.	Ji, Zhao-Ning: 2 articles (02/2018 - 12/2011)
5.	Yang, Xi: 2 articles (02/2018 - 10/2017)
6.	Li, Maidong: 2 articles (05/2014 - 03/2014)
7.	Zhang, Gang: 2 articles (05/2014 - 03/2014)
8.	Agarwal, Mukesh K: 2 articles (01/2011 - 06/2010)
9.	Agarwal, Munna L: 2 articles (01/2011 - 06/2010)
10.	Chakrabarti, Amitabha: 2 articles (01/2011 - 06/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "The object of this study is to investigate synthetic allosecurinine derivatives with considerable anticancer capacity against nine human cancer cell lines as well as mechanism of action. " 01/01/2023 - "We synthesized twenty-three novel allosecurinine derivatives and evaluated their antitumor activity against nine cancer cell lines for 72 h by MTT and CCK8 assays. " 01/01/2011 - "Securinine's clinical potential for AML can be seen from its ability to induce significant growth arrest in cell lines and patient samples as well as its activity in significantly impairing the growth of AML tumors in nude mice. " 12/01/2011 - "L-Securinine has an anti-tumor effect against colon cancer SW480 cell. " 12/01/2011 - "To investigate the anti-tumor effects of L-securinine inducing colon cancer SW480 cell autophagy and explore its potential molecular mechanism. "
2.	Leukemia 03/01/1999 - "To study whether securinine might induce apoptosis in human leukemia HL-60 cells. " 11/01/2022 - "Securinine also has the activity of inducing leukemia cell differentiation. " 11/12/2020 - "Based on our previously reported neuritogenic differentiation activity of synthetic dimeric derivatives of securinine, we explored the leukemia differentiation-induction activity of such as compound, SN3-L6. " 05/01/2014 - "L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway." 01/01/2011 - "We identified a natural compound securinine, as a leukemia differentiation-inducing agent. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 09/10/2015 - "We show that securinine displays favorable pharmaceutical properties, making it a promising compound for in vivo studies in neurodegenerative disease models. " 01/01/2017 - "Based on these results, aminoderivatives of securinine scaffold are promising compounds for development of new drugs for the treatment of neurodegenerative diseases." 01/01/2017 - "These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation."
4.	Lung Neoplasms (Lung Cancer) 12/15/2021 - "Securinine effectively prevented the proliferation of cervical, breast and lung cancer cells with an IC50 of 6, 10 and 11 μM respectively and induced minimal toxicity in HEK cell line. " 02/01/2018 - "L-securinine was a potential agent in the treatment of lung cancer by upregulation of SFRP1 gene expression and changing the SFRP1 gene methylation." 10/01/2017 - "L-securinine inhibited the proliferation of lung cancer cells; the half-maximal inhibitory concentration values were 8.92, 4.73 and 3.81 µg/ml, at 24, 36 and 48 h post-treatment, respectively. " 10/01/2017 - "L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation." 10/01/2017 - "The aim of the present study was to explore the effects of L-securinine on proliferation, and the methylation profile of the dickkopf-related protein 1 (DKK1) gene in human lung cancer cells and fibroblasts. "
5.	Prostatic Neoplasms (Prostate Cancer) 01/01/2019 - "The present study aims to evaluate the anticancer effect of L-securinine on androgen-independent prostate cancer (AIPC) DU145 cells. " 01/01/2019 - "L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways."

Related Drugs and Biologics

1.	Protein Disulfide-Isomerases
2.	Proteins (Proteins, Gene)
3.	Androgens
4.	VA 061 (VA061)
5.	PDI inhibitor 16f16
6.	Alkaloids
7.	Antineoplastic Agents (Antineoplastics)
8.	Therapeutic Uses
9.	Mitogen-Activated Protein Kinase Kinases (MEKs)
10.	Butyric Acid (Butanoic Acid)

Related Therapies and Procedures

1.	Therapeutics