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NUC-7738

Also Known As:

benzyl (2R)-2-((((2R,4S,5S)-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl)methoxy-phenoxyphosphoryl)amino)propanoate

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        NUC-7738: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - NUC-7738: 3

Experts

1.	Blagden, Sarah P: 1 article (12/2021)
2.	Bond, Gareth: 1 article (12/2021)
3.	Campo, Leticia: 1 article (12/2021)
4.	Chettle, James: 1 article (12/2021)
5.	De Zan, Erica: 1 article (12/2021)
6.	Easton, Alistair: 1 article (12/2021)
7.	Elshani, Mustafa: 1 article (12/2021)
8.	Ferrari, Valentina: 1 article (12/2021)
9.	Harrison, David J: 1 article (12/2021)
10.	Kazmi, Farasat: 1 article (12/2021)

Related Diseases

1.

Neoplasms (Cancer)

12/08/2022 - "NUC-7738 is now in Phase II, dose-escalation study in patients with advanced solid tumors."
01/01/2022 - "NUC-7738 is currently in a Phase I/II clinical study for the treatment of patients with advanced solid tumors. "
12/01/2021 - "We determine the IC50 of NUC-7738 using pharmacokinetics (PK) and conduct genome-wide analyses to identify its mechanism of action using different cancer model systems. "
12/01/2021 - "Our study provides proof that NUC-7738 overcomes cellular resistance mechanisms and supports its further clinical evaluation as a novel cancer treatment within the growing pantheon of anticancer ProTides."
12/01/2021 - "The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms In Vitro and in a First-In-Human Phase I Clinical Trial."

Related Drugs and Biologics

1.	ProTides
2.	Nucleotides
3.	Nucleosides
4.	Histidine (L-Histidine)
5.	Enzymes
6.	Carrier Proteins (Binding Protein)
7.	cordycepin
8.	phosphoramidic acid
9.	triphosphoric acid (triphosphate)