HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

EST64454

sigma1 receptor antagonist

Also Known As:

1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - EST64454: 2
  - Piperazines: 26
    - EST64454: 2

Experts

1.	Yeste, Sandra: 2 articles (12/2020 - 01/2020)
2.	Almansa, Carmen: 1 article (12/2020)
3.	Caamaño, Ana María: 1 article (12/2020)
4.	Cendán, Cruz Miguel: 1 article (12/2020)
5.	Díaz, José Luis: 1 article (12/2020)
6.	Enjo, Juan: 1 article (12/2020)
7.	García, Mónica: 1 article (12/2020)
8.	Lorente, Adriana: 1 article (12/2020)
9.	Maldonado, Rafael: 1 article (12/2020)
10.	Martín, Miquel: 1 article (12/2020)

Related Diseases

1.

01/01/2020 - "EST64454 is a selective sigma-1 receptor ligand intended for orally administered pain treatment that showed a promising profile in the lead optimization process. "
12/10/2020 - "The synthesis and pharmacological activity of a new series of pyrazoles that led to the identification of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone (9k, EST64454) as a σ1 receptor (σ1R) antagonist clinical candidate for the treatment of pain are reported. "

Related Drugs and Biologics

1.	EST64454
2.	Pyrazoles
3.	Ligands
4.	Sigma-1 Receptor