|1.||Maity, Biswanath: 1 article (04/2010)|
|2.||Patro, Birija Sankar: 1 article (04/2010)|
|3.||Chattopadhyay, Subrata: 1 article (04/2010)|
|4.||Yu, C: 1 article (05/2000)|
|5.||Liu, L F: 1 article (05/2000)|
|6.||LaVoie, E J: 1 article (05/2000)|
|7.||Liu, A: 1 article (05/2000)|
|8.||Makhey, D: 1 article (05/2000)|
04/15/2010 - "The CUVA treatment may represent a novel mechanism-based protocol for increasing the efficacy of coralyne in inducing apoptosis in both p53 wild-type and mutant tumor cells."
04/15/2010 - "The possibility of synergism between the topoisomerase inhibition by coralyne and its DNA photonicking properties being used to kill cancer cells was explored. "
04/15/2010 - "Topoisomerase inhibitor coralyne photosensitizes DNA, leading to elicitation of Chk2-dependent S-phase checkpoint and p53-independent apoptosis in cancer cells."
05/01/2000 - "These data suggest that heterocyclic compounds structurally related to coralyne can exhibit potent topo I poisoning activity despite the absence of an iminium cation within their structure. "
05/01/2000 - "While the benz[c]acridine derivatives evaluated as part of this study were devoid of topoisomerase poisoning activity, several dihydrobenz[a]acridines were able to enhance DNA cleavage in the presence of topo I. In contrast to certain protoberberine derivatives that did exhibit activity as topo II poisons, none of the benz[a]acridines derivatives enhanced DNA cleavage in the presence of topo II. Among the benz[a]acridines studied, 5,6-dihydro-3,4-methylenedioxy-9,10-dimethoxybenz[a]acridine, 13e, was the most potent topo I poison, with comparable potency to coralyne. "
06/15/1996 - "Protoberberine alkaloids (coralyne and its derivatives), which exhibit antileukemic activity in animal models, have been shown to be potent inducers of topoisomerase (topo) I-DNA cleavable complexes using purified recombinant human DNA topo I. Different from the structurally similar benzophenanthridine alkaloid nitidine (a dual poison of both topos I and II), coralyne and its derivatives have marginal poisoning activity against DNA topo II. Yeast cells expressing human DNA topo I are shown to be specifically sensitive to killing by coralyne derivatives and nitidine, suggesting that cellular DNA topo I is their cytotoxic target. "
|1.||trioctyl phosphine oxide (TOPO)
|6.||DNA (Deoxyribonucleic Acid)