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meridianin C

marine natural product known for its anti-cancer activity

Also Known As:

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-; 4-(5-Bromo-1H-indol-3-yl)-2-pyrimidinamine

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - meridianin C: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - meridianin C: 3

Experts

1.	Jang, Byeong-Churl: 3 articles (01/2020 - 10/2014)
2.	Lee, Jinho: 3 articles (01/2020 - 10/2014)
3.	Bishop-Bailey, David: 2 articles (01/2020 - 12/2018)
4.	Yadav, Anil Kumar: 2 articles (01/2020 - 12/2018)
5.	Choi, Jong-Soon: 2 articles (12/2018 - 10/2014)
6.	Hong, Victor Sukbong: 2 articles (12/2018 - 10/2014)
7.	Park, Yu-Kyoung: 2 articles (12/2018 - 10/2014)
8.	Cho, Hyorim: 1 article (01/2020)
9.	Do, Youngrok: 1 article (01/2020)
10.	Heo, Mihwa: 1 article (01/2020)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2020 - "The aim of the present study was to investigate the effects of meridianin C and its derivatives on MV4‑11 human acute myeloid leukemia cell growth. " 01/01/2020 - "Anti‑survival and pro‑apoptotic effects of meridianin C derivatives on MV4‑11 human acute myeloid leukemia cells."
2.	Neoplasms (Cancer) 12/01/2018 - "Meridianin C is a marine natural product known for its anti-cancer activity. " 10/03/2014 - "Meridianin C, a marine alkaloid, is a potent protein kinase inhibitor and has anti-cancer activity. "
3.	Leukemia 01/01/2020 - "Several meridianin C derivatives (compounds 7a‑j) were recently synthesized, and their inhibitory effects on pro‑viral integration site for Moloney murine leukemia virus (PIM) kinases, as well as their antiproliferative effects on human leukemia cells, were reported. " 10/03/2014 - "We have recently developed a series of meridianin C derivatives (compound 7a-7j) and reported their proviral integration Moloney Murine Leukemia Virus (pim) kinases' inhibitory and anti-proliferative effects on human leukemia cells. "
4.	Tongue Neoplasms (Tongue Neoplasm) 12/01/2018 - "Here, we investigated the effect of meridianin C on the proliferation of four different human tongue cancer cells, YD-8, YD-10B, YD-38 and HSC-3. " 12/01/2018 - "Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3."
5.	Squamous Cell Carcinoma of Head and Neck 12/01/2018 - "At present, the anti-tumour effects of meridianin C on oral squamous cell carcinoma are unknown. "

Related Drugs and Biologics

1.	proto-oncogene proteins pim
2.	Protein Kinase Inhibitors
3.	Alkaloids