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4- (4- acetylpiperazin- 1- yl)- 2- (1H- imidazol- 1- yl)aniline

a free radical scavenger with protective activity against light-induced photoreceptor degeneration; structure in first source

Also Known As:

NSP-116

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - 4-(4-acetylpiperazin-1-yl)-2-(1H-imidazol-1-yl)aniline: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 4-(4-acetylpiperazin-1-yl)-2-(1H-imidazol-1-yl)aniline: 3

Experts

1.	Hara, Hideaki: 3 articles (01/2021 - 01/2016)
2.	Shimazawa, Masamitsu: 3 articles (01/2021 - 01/2016)
3.	Nakamura, Shinsuke: 2 articles (01/2021 - 11/2019)
4.	Nishinaka, Anri: 1 article (01/2021)
5.	Nitta, Koki: 1 article (01/2021)
6.	Tanaka, Miruto: 1 article (01/2021)
7.	Yamamoto, Takumi: 1 article (01/2021)
8.	Imai, Takahiko: 1 article (11/2019)
9.	Iwata, Sena: 1 article (11/2019)
10.	Miyo, Daisuke: 1 article (11/2019)

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy) 01/01/2016 - "These findings suggest that NSP-116 has protective effects against light-induced photoreceptor degeneration in vitro and in vivo as a free radical scavenger, and it may be a novel therapeutic agent for retinal degenerative disorders, such as dry age-related macular degeneration (AMD)."
2.	Hemorrhagic Stroke 11/01/2019 - "The purpose of this study was to investigate the effects of NSP-116 on both ischemic and hemorrhagic stroke models. " 11/01/2019 - "A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models."
3.	Stroke (Strokes) 11/01/2019 - "Collectively, our findings indicated that oral administration of NSP-116 attenuates both ischemic and hemorrhagic brain injuries after stroke."
4.	Reperfusion Injury 11/01/2019 - "A novel free radical scavenger, NSP-116, has anti-oxidative effect and may ameliorate reperfusion injury. "
5.	Retinal Vein Occlusion 01/01/2021 - "Oral administration of NSP-116, a free radical scavenger, suppresses the symptoms of retinal vein occlusion in the murine model."

Related Drugs and Biologics

1.	Free Radical Scavengers
2.	Retinaldehyde (Retinal)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Oral Administration