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T-3764518

a stearoyl coenzyme A desaturase 1 inhibitor with antineoplastic activity; structure in first source

Also Known As:

(5-(6-(4-(trifluoromethyl)-4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)pyridazin-3-yl)-1,3,4-oxadiazol-2-yl)methanol

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        T-3764518: 2
  - Pyridazines: 11
    - T-3764518: 2

Experts

1.	Imamura, Keisuke: 2 articles (07/2017 - 01/2017)
2.	Sumi, Hiroyuki: 2 articles (07/2017 - 01/2017)
3.	Aoyama, Kazunobu: 1 article (07/2017)
4.	Araki, Hideo: 1 article (07/2017)
5.	Hara, Takahito: 1 article (07/2017)
6.	Hirayama, Megumi: 1 article (07/2017)
7.	Honda, Kohei: 1 article (07/2017)
8.	Kakoi, Kazuyo: 1 article (07/2017)
9.	Kitazawa, Satoshi: 1 article (07/2017)
10.	Maezaki, Hironobu: 1 article (07/2017)

Related Diseases

1.

Colorectal Neoplasms (Colorectal Cancer)

01/01/2017 - "Herein, by using a biologically annotated compound library, we performed a large-scale combination screening with Stearoyl-CoA desaturase-1 (SCD1) inhibitor, T-3764518, which partially inhibits colorectal cancer cell proliferation. "
07/15/2017 - "T-3764518 inhibited stearoyl-CoA desaturase-catalyzed conversion of stearoyl-CoA to oleoyl-CoA in colorectal cancer HCT-116 cells and their growth. "

Related Drugs and Biologics

1.	stearoyl-coenzyme A (stearoyl-CoA)
2.	Stearoyl-CoA Desaturase
3.	oleoyl-coenzyme A