TMP195

01/01/2017 - "Here, we utilize a macrophage-dependent autochthonous mouse model of breast cancer to demonstrate that in vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. "
01/01/2022 - "TMP195, a selective class IIa HDAC inhibitor, has been reported to be effective against breast cancer. "

12/29/2019 - "Furthermore, we did not find clear evidence of TMP195 resistance conferred by ABCB1 or ABCG2, suggesting that these transporters are unlikely to play a significant role in the development of resistance to TMP195 in cancer patients."
12/29/2019 - "We reveal that in vitro TMP195 treatment significantly enhances drug-induced apoptosis and sensitizes multidrug-resistant cancer cells overexpressing ABCB1 or ABCG2 to anticancer drugs. "
08/01/2017 - "In a new report Guerriero and colleagues demonstrate that a novel HDAC Class IIa inhibitor, TMP195, can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response."
01/01/2022 - "In this study, we found that TMP195 significantly reduced the tumor burden in two mouse models of colitis-associated colorectal cancer (CAC) and subcutaneous tumor. "
01/01/2020 - "In this study, we examine the effect of a Class IIa-selective HDAC inhibitor (TMP195) on the phagocytic response to opsonised tumor cells or non-opsonised targets by MDMs derived from CLL patients. "

01/01/2022 - "The present study revealed that the combination of TMP195 and PD-1 blockade may provide a therapeutic strategy for colorectal cancer."
01/01/2022 - "However, the role and mechanism of TMP195 in colorectal cancer remain unknown. "
01/01/2022 - "TMP195 Exerts Antitumor Effects on Colorectal Cancer by Promoting M1 Macrophages Polarization."
01/01/2022 - "TMP195 had no direct effect on the proliferation of colorectal cancer cells, and its antitumor effect on the colorectal cancer disappeared when macrophages were partly depleted by clodronate liposomes. "

01/01/2022 - "In this study, we found that TMP195 significantly reduced the tumor burden in two mouse models of colitis-associated colorectal cancer (CAC) and subcutaneous tumor. "

12/01/2020 - "Class IIa HDAC inhibitor TMP195 alleviates lipopolysaccharide-induced acute kidney injury."