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AMG2850

a TRPM8 channel antagonist; structure in first source

Also Known As:

8-(4-(trifluoromethyl)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - AMG2850: 2

Experts

1.	Gavva, Narender R: 2 articles (04/2015 - 03/2014)
2.	Lehto, Sonya G: 2 articles (04/2015 - 03/2014)
3.	Wang, Weiya: 2 articles (04/2015 - 03/2014)
4.	Youngblood, Beth D: 2 articles (04/2015 - 03/2014)
5.	Davis, Carl: 1 article (04/2015)
6.	Kerstein, Patrick C: 1 article (04/2015)
7.	Stucky, Cheryl L: 1 article (04/2015)
8.	Wang, Judy: 1 article (04/2015)
9.	Weyer, Andy D: 1 article (04/2015)
10.	Wild, Kenneth D: 1 article (04/2015)

Related Diseases

1.	Pain (Aches) 04/01/2015 - "Here, we evaluated the therapeutic potential in pain of AMG2850 ((R)-8-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide), a small molecule antagonist of TRPM8 by in vitro and in vivo characterization. " 04/01/2015 - "However, AMG2850 did not produce a significant therapeutic effect in rat models of inflammatory mechanical hypersensitivity or neuropathic tactile allodynia at doses up to 100 mg/kg. The lack of efficacy suggests that either TRPM8 does not play a role in mediating pain in these models or that a higher level of target coverage is required. "
2.	Hypothermia 03/26/2014 - "In the same experimental setup, blocking the melastatin-8 (TRPM8) channel with AMG2850 (30 mg/kg) attenuated cold-defense mechanisms and led to hypothermia. "
3.	Hypersensitivity (Allergy) 04/01/2015 - "AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia." 04/01/2015 - "However, AMG2850 did not produce a significant therapeutic effect in rat models of inflammatory mechanical hypersensitivity or neuropathic tactile allodynia at doses up to 100 mg/kg. The lack of efficacy suggests that either TRPM8 does not play a role in mediating pain in these models or that a higher level of target coverage is required. "
4.	Hyperalgesia 04/01/2015 - "AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia." 04/01/2015 - "However, AMG2850 did not produce a significant therapeutic effect in rat models of inflammatory mechanical hypersensitivity or neuropathic tactile allodynia at doses up to 100 mg/kg. The lack of efficacy suggests that either TRPM8 does not play a role in mediating pain in these models or that a higher level of target coverage is required. "

Related Drugs and Biologics

1.	Therapeutic Uses