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CCT327

antineoplastic

Also Known As:

2-(5-methylselenophen-2-yl)-6,7-methylenedioxyquinolin-4-one

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        CCT327: 1
Organic Chemicals: 133
- Organoselenium Compounds: 63
  - CCT327: 1

Experts

1.	Ho, Chi-Tang: 1 article (09/2014)
2.	Huang, Li-Jiau: 1 article (09/2014)
3.	Kuo, Daih-Huang: 1 article (09/2014)
4.	Kuo, Sheng-Chu: 1 article (09/2014)
5.	Lee, Jang-Chang: 1 article (09/2014)
6.	Lin, Ying-Chao: 1 article (09/2014)
7.	Liu, Yan-Jin: 1 article (09/2014)
8.	Way, Tzong-Der: 1 article (09/2014)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2014 - "Taken together, these results showed that CCT327 combined with TRAIL treatment may provide an effective therapeutic strategy for cancer. " 09/01/2014 - "This study investigated the effects of 2-(5-methylselenophen‑2‑yl)‑6,7‑methylenedioxyquinolin‑4-one (CCT327), an analogue of quinolin-4-one, on the sensitization of cancer cells to TRAIL and on TRAIL‑induced apoptosis in TRAIL‑resistance human leukemia cells (HL60‑TR). "
2.	Leukemia 09/01/2014 - "This study investigated the effects of 2-(5-methylselenophen‑2‑yl)‑6,7‑methylenedioxyquinolin‑4-one (CCT327), an analogue of quinolin-4-one, on the sensitization of cancer cells to TRAIL and on TRAIL‑induced apoptosis in TRAIL‑resistance human leukemia cells (HL60‑TR). " 09/01/2014 - "CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells."

Related Drugs and Biologics

1.	Death Domain Receptors
2.	Proteins (Proteins, Gene)