HLM006474

an inhibitor of E2F transcription factor; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Carcinogenesis 11/29/2012 - "More importantly, exposing retinoblastoma-prone fetuses to small molecule inhibitors of E2f (HLM006474) or Cdk (R547) for merely 1 week dramatically inhibited subsequent tumorigenesis in adult mice. "
2.	Retinoblastoma (Glioblastoma, Retinal) 11/29/2012 - "More importantly, exposing retinoblastoma-prone fetuses to small molecule inhibitors of E2f (HLM006474) or Cdk (R547) for merely 1 week dramatically inhibited subsequent tumorigenesis in adult mice. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "To test this hypothesis, we have examined the activity of HLM006474 (a small molecule pan-E2F inhibitor) in lung cancer cell lines as a single agent and in combination with other compounds. " 01/01/2014 - "Taken together, these results suggest that HLM006474 may have efficacy in lung cancer and may be useful in combination with taxanes. "

1.	Taxoids (Taxanes)