|1.||Katano, Mitsuo: 9 articles (06/2013 - 09/2004)|
|2.||Matsui, William: 6 articles (01/2012 - 03/2007)|
|3.||Maitra, Anirban: 6 articles (12/2010 - 03/2007)|
|4.||Fendrich, Volker: 5 articles (04/2014 - 03/2007)|
|5.||Feldmann, Georg: 5 articles (12/2010 - 03/2007)|
|6.||Renoux, Brigitte: 4 articles (01/2015 - 04/2010)|
|7.||Papot, Sébastien: 4 articles (01/2015 - 04/2010)|
|8.||Onishi, Hideya: 4 articles (06/2013 - 12/2011)|
|9.||Mahato, Ram I: 4 articles (11/2012 - 06/2011)|
|10.||Xie, Jingwu: 4 articles (12/2011 - 10/2004)|
03/01/2007 - "The development of hedgehog inhibitors based on the action of cyclopamine holds promise for novel treatments to slow or arrest tumor growth."
01/01/2014 - "The present study showed that the drug cyclopamine, which blocks the hedgehog signaling pathway, could reduce cancer cell growth and proliferation and induce cell apoptosis. "
12/01/2010 - "Initial translational studies conducted using cyclopamine, a small-molecule inhibitor of the Smoothened (SMO) component of the Hedgehog pathway, demonstrated that pharmacological blockade of aberrant Hedgehog signaling has the potential to inhibit tumor initiation, progression and metastatic spread. "
07/01/2010 - "Previous studies have used the Hh-inhibitory alkaloid cyclopamine to treat Hh-dependent tumor growth. "
06/01/2015 - "Cyclopamine (CPA), a potent inhibitor for sonic hedgehog pathway (SHH), shows great promises in PDAC treatment, including the disruption of tumor-associated stroma, and enhancement of radiation therapy. "
|2.||Prostatic Neoplasms (Prostate Cancer)
12/01/2011 - "Our study suggests that drugs like cyclopamine that interfere with Shh signaling could be beneficial in preventing AI progression in prostate cancer cells."
03/01/2014 - "To explore the effects of cyclopamine on the proliferation and apoptosis of LNCaP cells and the expression of the PCA3 gene in human prostate cancer in vitro. "
03/01/2014 - "[Effects of cyclopamine on the proliferation and apoptosis of LNCaP cells and expression of the PCA3 gene in human prostate cancer]."
03/18/2013 - "Functionally, knockdown of Kindlin-2 cooperates with cyclopamine, a Smoothened antagonist, to decrease the viability of prostate cancer cells. "
02/01/2012 - "Blockade of the hedgehog (Hh) signaling pathway, an important pathway involved in stem cell self-renewal, by cyclopamine leads to long-term prostate cancer regression without recurrence, strongly suggesting the connection between Hh pathway and prostate CSCs. "
12/01/2014 - "Inhibitory potential of postnatal treatment with cyclopamine, a hedgehog signaling inhibitor, on medulloblastoma development in Ptch1 heterozygous mice."
12/15/2010 - "We also evaluated the effect of combined therapy with a Hedgehog inhibitor (cyclopamine) in GBM and medulloblastoma lines, and in primary human GBM cultures. "
10/01/2010 - "Cyclopamine inhibits the SHH pathway in medulloblastoma cell lines, but its effect on cPNET and pPNET cell lines has not been well established yet. "
09/01/2010 - "We induced medulloblastomas by retrovirus-mediated expression of Shh and HGF, after which we treated the mice systemically with (a) HGF-neutralizing monoclonal antibody L2G7, (b) Shh signaling inhibitor cyclopamine, (c) Shh-neutralizing monoclonal antibody 5E1, (d) L2G7 + cyclopamine, or (e) L2G7 + 5E1. "
01/01/2007 - "The Hedgehog antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and Gli1, lowered BclII levels, and increased apoptosis in DAOY and UW228 medulloblastoma cells. "
|4.||Psoriasis (Pustulosis Palmaris et Plantaris)
09/01/2006 - "Although considerable research and clinical trials lie ahead, cyclopamine-induced Hh inhibition may represent the latest mechanistic pathway to combat psoriasis."
09/01/2006 - "The steroidal alkaloid cyclopamine, a direct inhibitor of the hedgehog (Hh) intracellular signaling pathway, has demonstrated promising initial results in the treatment of psoriasis. "
09/01/2006 - "Cyclopamine: inhibiting hedgehog in the treatment of psoriasis."
01/01/2004 - "We aimed to develop a mechanism-based treatment for psoriasis with cyclopamine. "
01/01/2004 - "Cyclopamine, hedgehog and psoriasis."
|5.||Osteosarcoma (Osteogenic Sarcoma)
10/01/2007 - "We here demonstrate that cyclopamine exhibits a high efficacy against the osteosarcoma cell lines HOS, SaOS and OS-KA, a self-established primary osteosarcoma cell line. "
10/01/2007 - "This study investigates the impact of the steroidal alkaloid and Hh-inhibitor cyclopamine on osteosarcoma cells. "
03/01/2012 - "Recently, the impact of cyclopamine, which inhibits Hedgehog signaling by binding to the receptor Smoothened, was shown in different human osteosarcoma cell lines in vitro and in vivo. "
01/01/2010 - "Inhibition of SMO by cyclopamine, a specific inhibitor of SMO, slowed the growth of osteosarcoma in vitro. "
10/01/2007 - "Our results provide evidence for the potency of the Hh-inhibitor cyclopamine as a future treatment of osteosarcomas."
|3.||Epidermal Growth Factor Receptor (EGF Receptor)
|9.||Epidermal Growth Factor (EGF)
|2.||Homologous Transplantation (Allograft)
|3.||Heterologous Transplantation (Xenotransplantation)
|4.||Drug Therapy (Chemotherapy)