cladosporin

antifungal metabolite from Cladosporium cladosporioides; toxic, minor metabolite of Aspersillus flavus; inhibits tRNA synthetase in Plasmodium falciparum

Also Known As:

3,4-dihydro-6,8-dihydroxy-3-(6-methyltetrahydropyran- 2-ylmethyl)isocoumarin; asperentin; isocladosporin; 3,4-dihydro-6,8-dihydroxy-3-(tetrahydro-6- methyl-2H-pyran-2-yl)methylisocoumarin

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Isocoumarins: 26
        cladosporin: 8
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Isocoumarins: 26
        cladosporin: 8

Experts

1.	Sharma, Amit: 3 articles (11/2021 - 06/2014)
2.	Babbar, Palak: 1 article (11/2021)
3.	Das, Pronay: 1 article (11/2021)
4.	Manickam, Yogavel: 1 article (11/2021)
5.	Mankad, Yash: 1 article (11/2021)
6.	Parvez, Suhel: 1 article (11/2021)
7.	Reddy, D Srinivasa: 1 article (11/2021)
8.	Yadav, Swati: 1 article (11/2021)
9.	Chhibber-Goel, Jyoti: 1 article (01/2019)
10.	Aldemir, Hülya: 1 article (06/2017)

Related Diseases

1.	Malaria 11/01/2021 - "Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites." 01/01/2019 - "Cladosporin (CLD) is a fungal metabolite that kills the malaria parasite via inhibiting its cytoplasmic lysyl-tRNA synthetase (KRS) and abrogating protein translation. " 06/01/2014 - "Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin." 01/01/2023 - "Due to its exquisite selectivity towards pathogenic parasites, cladosporin has become a very promising lead compound for developing antiparasitic drugs to treat drug-resistant malaria and cryptosporidiosis infections. "
2.	Infections 01/11/2016 - "The antimalarial agent cladosporin is a nanomolar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against both blood- and liver-stage infection. " 01/01/2023 - "Due to its exquisite selectivity towards pathogenic parasites, cladosporin has become a very promising lead compound for developing antiparasitic drugs to treat drug-resistant malaria and cryptosporidiosis infections. "
3.	Inflammation (Inflammations) 04/25/2011 - "Transcriptional responses of 13 inflammation/respiratory burst-associated genes (KC=Cxcl1, Cxcl2, Cxcl5, Cxcl10, Ccl3, Ccl112, Ccl20, IL-1β, Il-6, ifi27 Tnfα, iNOS and Blvrb) were evaluated in mouse AMs exposed to a 1ml (10(-8)mol) dose of either pure atranone C, brevianimide, cladosporin, curdlan, LPS, neoechinulin A & B, sterigmatocystin or TMC-120A for 2h, 4h and 12h PE using customized reverse transcription (RT)-PCR based arrays. "
4.	Type 2 Diabetes Mellitus (MODY) 06/21/2017 - "Asperentin B (1) is discussed as possible therapeutic agents for type 2 diabetes and sleeping sickness."
5.	Cryptosporidiosis 01/01/2023 - "Due to its exquisite selectivity towards pathogenic parasites, cladosporin has become a very promising lead compound for developing antiparasitic drugs to treat drug-resistant malaria and cryptosporidiosis infections. "

Related Drugs and Biologics

1.	Lysine-tRNA Ligase
2.	Isocoumarins
3.	Uridine
4.	Uracil
5.	Sterigmatocystin
6.	Leucine (L-Leucine)
7.	Antiparasitic Agents (Antiparasitics)
8.	Antimalarials (Antimalarial Agents)
9.	neoechinulin A
10.	TMC 120A