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1,2-bis(3,5-dioxopiperazin-1-yl)ethane

Also Known As:

ICRF 154; ICRF-154

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - Diketopiperazines: 59
      - Razoxane: 164
        1,2-bis(3,5-dioxopiperazin-1-yl)ethane: 13

Experts

1.	Lu, Da-Yong: 3 articles (09/2010 - 07/2006)
2.	Lu, Ting-Ren: 2 articles (09/2010 - 01/2010)
3.	Ding, Jian: 2 articles (07/2006 - 06/2005)
4.	Huang, Min: 2 articles (07/2006 - 06/2005)
5.	Eastmond, David A: 1 article (01/2013)
6.	Hasegawa, Leslie S: 1 article (01/2013)
7.	Vuong, Minh C: 1 article (01/2013)
8.	Xu, Bin: 1 article (07/2006)
9.	Xu, Cheng-Hui: 1 article (07/2006)
10.	Zhu, Hong: 1 article (07/2006)

Related Diseases

1.	Lymphoma (Lymphomas) 11/01/1991 - "Early phase II study of MST-16[4,4-(1,2-ethanediyl) bis (1-isobutoxycarbonyloxy-methyl-2, 6-piperazinedione], a derivative of ICRF-154, on malignant lymphoma was conducted by multi-institutional cooperative group. "
2.	Neoplasms (Cancer) 03/01/1975 - "Similar pretreatment before immunization with allogeneic tumor cells also led to enhanced T-killer cell activity, but only in ICRF 154- and CPA-treated mice. " 03/01/1975 - "Moreover, when irradiated tumor cells were given for 3 days with CPA or ICRF 154, enhancement rather than inhibition of cytotoxicity was the usual response. " 08/01/1992 - "Against lymphoid malignancies, ICRF-154 would be advantageous when administered simultaneously with many anticancer agents. " 04/01/1985 - "The antitumor activities of three new analogs were compared with bimolane, ICRF-154 and razoxane against four rodent tumors. " 01/20/2013 - "ICRF-154 and bimolane have been used for the treatment of cancer, psoriasis, and uveitis in humans. "
3.	Neoplasm Metastasis (Metastasis) 07/01/2006 - "Bisdioxopiperazines, including ICRF-154 and razoxane (ICRF-159, Raz), are a family of anticancer agents developed in the UK, specifically targeting neoplastic metastases. " 09/01/2010 - "Bisdioxopiperazine (Biz) compounds, including ICRF-154 and razoxane (ICRF-159, Raz), are anticancer agents developed in the UK specifically targeting tumor metastases. " 01/01/2010 - "Bisdioxopiperazine compounds, including ICRF-154 and razoxane (ICRF-159, Raz), are anticancer agents developed in the UK specifically targeting tumor metastases. " 06/20/2005 - "Anticancer bisdioxopiperazines, including ICRF-154, razoxane (Raz, ICRF-159) and ICRF-193, are a family of anticancer agents developed in the UK, especially targeting metastases of neoplasms. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 02/01/1997 - "The patient was a 36-year-old Chinese man with a longstanding psoriasis for which he had received bimolane and ICRF-154 therapy. " 02/01/1997 - "Translocation t(7;11)(P15;P15) in a patient with therapy-related acute myeloid leukemia following bimolane and ICRF-154 treatment for psoriasis." 01/20/2013 - "ICRF-154 and bimolane have been used for the treatment of cancer, psoriasis, and uveitis in humans. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/01/1997 - "Translocation t(7;11)(P15;P15) in a patient with therapy-related acute myeloid leukemia following bimolane and ICRF-154 treatment for psoriasis."

Related Drugs and Biologics

1.	sobuzoxane
2.	3,6- bis(5- chloro- 2- piperidyl)- 2,5- piperazinedione
3.	Razoxane
4.	Antineoplastic Agents (Antineoplastics)
5.	bimolane
6.	4,4'- (1,2- dimethyl- 1,2- ethanediyl)bis- 2,6- piperazinedione
7.	Topoisomerase II Inhibitors
8.	Proteins (Proteins, Gene)
9.	Type II DNA Topoisomerases (Topoisomerase II)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics