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pipoxolan (BR 18)

synonyms BR-18 & rowapraxin refer to HCl; structure

Also Known As:

BR 18; 5,5-diphenyl-2-(beta-N-piperidinoethyl)-1,3-dioxolan-4-one; BR-18; Rowapraxin; pipoxolan monohydrochloride

Networked: 17 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Dioxolanes: 3
      - pipoxolan: 17

Experts

1.	Rodrigues, Fabrício Ávila: 3 articles (07/2020 - 12/2012)
2.	Sheu, Ming-Jyh: 3 articles (11/2017 - 05/2010)
3.	Tsai, Huei-Yann: 3 articles (01/2013 - 05/2010)
4.	Leighl, Natasha B: 3 articles (06/2012 - 04/2005)
5.	Shepherd, Frances A: 3 articles (06/2012 - 04/2005)
6.	DaMatta, Fábio Murilo: 2 articles (07/2020 - 01/2014)
7.	Chou, Pei-Yu: 2 articles (11/2017 - 05/2010)
8.	Lee, Min-Min: 2 articles (11/2017 - 07/2015)
9.	Lin, Sung-Yuan: 2 articles (11/2017 - 05/2010)
10.	Debona, Daniel: 2 articles (01/2014 - 12/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/01/2022 - "Phase II study to investigate the efficacy of trastuzumab biosimilar (Herzuma®) plus treatment of physician's choice (TPC) in patients with heavily pretreated HER-2+ metastatic breast cancer (KCSG BR 18-14/KM10B)."
2.	Hyperplasia 01/01/2013 - "Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2/9 and Ras/MEK/ERK signaling pathways."
3.	Brain Ischemia (Cerebral Ischemia) 01/01/2013 - "Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2/9 and Ras/MEK/ERK signaling pathways."
4.	Neoplasms (Cancer) 02/01/2020 - "In patients >65 years secondary neoplasia occurred more frequently after FCR treatment [28 of 86 (32.6%) patients] as compared with BR [18 of 107 (16.8%) patients; p = 0.011]. " 09/01/2010 - "Pipoxolan HCl (5,5-diphenyl-2-(2'-piperidino-ethyl)-1,3-dioxolane-4-one hydrochloride) is a compound containing a dioxolan moiety that was reported to induce apoptosis in cancer cells. " 05/01/2010 - "Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase." 07/05/2015 - "This study examined the anti-metastatic effects of pipoxolan on lung adenocarcinoma cancer cells (i.e. " 09/01/2010 - "Taken together, the data from our studies indicate that pipoxolan possesses potent anti-leukemia activity and is a potential novel alternative cancer therapeutic agent for human leukemia."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/01/2012 - "In the present study, expression of ER-beta was investigated by immunohistochemistry using tissue samples from two cohorts: non-small cell lung cancer (NSCLC) diagnosed in 1999 in Manitoba and advanced NSCLC patients from the NCIC-CTG BR.18 trial. " 04/20/2005 - "Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18."

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