Clozapine FDA Link Generic

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Also Known As:

Clozaril; Leponex; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-

Pharmalogical Action Categories:

Antipsychotic Agents
GABA Antagonists
Serotonin Antagonists

-

Heterocyclic Compounds: 23

-

3-Ring Heterocyclic Compounds

-

Dibenzazepines

*

Clozapine: 2881

Create Custom RSS News Feed:
	Clozapine (Clozaril)

Alamo Pharmaceuticals Llc Product Research

Products