Tom van der Poll Selected Research

Pneumonia (Pneumonitis)

07/2008	Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.
03/2008	Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor.
03/2008	Platelet-Activating Factor Receptor Contributes to Host Defense against Pseudomonas aeruginosa Pneumonia but Is Not Essential for the Accompanying Inflammatory and Procoagulant Response.
01/2008	Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation.
01/2008	Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury.
12/2007	Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia.
11/2007	Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.
10/2007	Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae.
05/2007	Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats.
02/2007	Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia.
06/2006	Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.
04/2006	Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice.
03/2006	Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
01/2006	The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia.
01/2006	Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia.
01/2006	Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia.
10/2005	A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis.
12/2004	Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
11/2004	LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.
06/2004	Salmeterol, a beta2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice.
02/2004	Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice.
05/2002	Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus.
02/2002	Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia.
01/2002	Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice.

Articles by Research Topic

Disease

24	Pneumonia (Pneumonitis) 07/2008 - 01/2002
11	Pneumococcal Pneumonia 05/2007 - 01/2002
10	Endotoxemia 04/2008 - 04/2002
8	Sepsis (Septicemia) 07/2007 - 05/2004
6	Inflammation 05/2007 - 05/2003
5	Peritonitis 09/2008 - 10/2003
4	Human Influenza (Influenza) 12/2007 - 06/2004
4	Infection 02/2006 - 06/2004
3	Tuberculosis 08/2007 - 10/2005
3	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 05/2003 - 04/2003
2	Pancreatitis 08/2008 - 05/2005
2	Ventilator-Associated Pneumonia (Pneumonia, Ventilator Associated) 04/2008 - 01/2004
2	Melioidosis 08/2007 - 07/2007
2	Respiratory Tract Infections (Respiratory Tract Infection) 06/2006 - 10/2003
1	Hyperglycemia 09/2008
1	Hyperinsulinism (Hyperinsulinemia) 09/2008
1	Hyperamylasemia 08/2008
1	Shock 09/2007
1	Bacterial Meningitis 03/2006
1	Acute-Phase Reaction 01/2006
1	Chronic Pancreatitis 03/2005
1	Scrub Typhus (Typhus, Scrub) 11/2004
1	Leptospirosis 11/2004
1	Reperfusion Injury 05/2004
1	Visceral Leishmaniasis (Kala Azar) 01/2004
1	Pulmonary Tuberculosis 08/2003
1	Disseminated Intravascular Coagulation 06/2003
1	Legionnaires' Disease (Legionnaire's Disease) 08/2002

Drug/Important Bio-Agent (IBA)

5	lipoteichoic acidIBA 07/2008 - 05/2002
5	platelet activating factor receptorIBA 03/2008 - 08/2003
5	Interleukin-18 (Interleukin 18)IBA 10/2007 - 01/2002
5	Toll-Like Receptor 4IBA 09/2007 - 08/2002
5	Protein CIBA 05/2007 - 06/2003
4	Toll-Like Receptor 2IBA 07/2007 - 03/2004
4	lipopolysaccharide-binding proteinIBA 03/2006 - 12/2003
3	Thromboplastin (Tissue Factor)IBA 06/2006 - 06/2004
3	Interleukin-10 (Interleukin 10)IBA 01/2006 - 04/2003
3	Protein Kinases (Protein Kinase)IBA 01/2004 - 04/2002
3	Interleukin-1 (Interleukin 1)IBA 10/2003 - 02/2002
2	Prednisolone (Predate)FDA LinkGeneric 04/2008 - 02/2007
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2008 - 01/2006
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 12/2007 - 12/2006
2	Interferon-gamma (Interferon, gamma)IBA 08/2007 - 11/2004
2	Plasminogen Activators (Plasminogen Activator)IBA 02/2007 - 11/2006
2	Factor VIIa (Activated Factor VII)IBA 06/2006 - 06/2004
2	Interleukin-12 (IL 12)IBA 06/2006 - 01/2005
2	LeptinIBA 04/2006 - 11/2005
2	CytokinesIBA 11/2004 - 01/2004
2	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2004 - 04/2002
2	Interleukin-6 (Interleukin 6)IBA 05/2002 - 01/2002
1	AdiponectinIBA 09/2008
1	Cholinergic ReceptorsIBA 09/2008
1	Mitogen-Activated Protein KinasesIBA 08/2008
1	CNI 1493IBA 08/2008
1	Biological Markers (Surrogate Marker)IBA 03/2008
1	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2008
1	ethyl pyruvateIBA 11/2007
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 08/2007
1	Messenger RNA (mRNA)IBA 06/2007
1	Lipoproteins (Lipoprotein)IBA 05/2007
1	PhospholipidsIBA 01/2007
1	Tissue Plasminogen Activator (Alteplase)FDA Link 07/2006
1	Dobutamine FDA LinkGeneric 05/2006
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2006
1	Chemotactic FactorsIBA 03/2006
1	adjuvant P40 (P 40)IBA 03/2006
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 02/2006
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2006
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2006
1	CCR2 ReceptorsIBA 01/2006
1	Carboxypeptidase U (TAFI)IBA 11/2005
1	ThrombomodulinIBA 10/2005
1	troglitazone (Rezulin)FDA Link 03/2005
1	Mannose (D-Mannose)IBA 12/2004
1	lipoarabinomannan (LAM)IBA 12/2004
1	salmeterol (Serevent)FDA Link 06/2004
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 04/2004
1	Carbon MonoxideIBA 01/2004
1	CXCR ReceptorsIBA 01/2004
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2003
1	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 07/2003
1	ChemokinesIBA 07/2003
1	Peptidoglycan (Murein)IBA 05/2002
1	CCR5 Receptors (CCR5 Receptor)IBA 04/2002
1	Streptococcus pneumoniae plY proteinIBA 01/2002

Therapy/Procedure

2	Artificial Respiration (Mechanical Ventilation) 04/2008 - 01/2008
1	Positive-Pressure Respiration (PEEP) 01/2008