Detlef Zillikens Selected Research

Bullous Pemphigoid (Pemphigoid)

12/2007	A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid.
09/2007	Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies.
11/2006	Localisation of bullous pemphigoid antigen 180 (BP180) in cultured human keratinocytes: functionally relevant modification by calcium.
01/2006	[Anti-laminin 5 mucous membrane pemphigoid]
09/2005	Treatment of bullous pemphigoid with dapsone, methylprednisolone, and topical clobetasol propionate: a retrospective study of 62 cases.
12/2004	Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.
12/2003	The autoantigen of anti-p200 pemphigoid is an acidic noncollagenous N-linked glycoprotein of the cutaneous basement membrane.
12/2003	The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini.
04/2003	Trehalose conserves expression of bullous pemphigoid antigen 180 during desiccation and freezing.
03/2003	Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies.
02/2003	Extracellular cleavage of bullous pemphigoid antigen 180/type XVII collagen and its involvement in hemidesmosomal disassembly.
07/2002	Subacute prurigo variant of bullous pemphigoid: autoantibodies show the same specificity compared with classic bullous pemphigoid.
07/2002	Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age.
06/2002	A highly sensitive and simple assay for the detection of circulating autoantibodies against full-length bullous pemphigoid antigen 180.
04/2002	Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin.
01/2002	Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoid gestationis regarding the fine specificity of autoantibodies to the BP180 NC16A domain.

Articles by Research Topic

Disease

16	Bullous Pemphigoid (Pemphigoid) 12/2007 - 01/2002
6	Pemphigus (Pemphigus Vulgaris) 08/2008 - 04/2003
3	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 08/2008 - 12/2004
3	Blister (Bulla) 04/2007 - 04/2003
3	Pemphigoid Gestationis (Herpes Gestationis) 04/2006 - 01/2002
3	Benign Mucous Membrane Pemphigoid (Cicatricial Pemphigoid) 12/2004 - 01/2002
2	Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis) 05/2008 - 04/2007
2	Muscular Dystrophies (Muscular Dystrophy) 04/2004 - 06/2002
2	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 04/2004 - 06/2002
1	Dissociative Disorders (Fugue) 11/2005
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 03/2005
1	Prurigo 07/2002
1	Skin Diseases 03/2002

Drug/Important Bio-Agent (IBA)

17	AutoantibodiesIBA 09/2007 - 01/2002
6	Immunoglobulin G (IgG)IBA 08/2008 - 01/2002
6	AntigensIBA 11/2006 - 04/2002
5	collagen type XVII (collagen XVII)IBA 09/2007 - 02/2003
4	Immunoglobulin A (IgA)IBA 12/2006 - 01/2002
3	Desmoglein 3IBA 09/2007 - 04/2003
3	Desmoglein 1IBA 09/2007 - 11/2005
2	DesmogleinsIBA 08/2008 - 11/2005
2	rituximab (Mabthera)FDA Link 05/2008 - 02/2006
2	Methylprednisolone FDA LinkGeneric 12/2007 - 09/2005
2	kalininIBA 01/2006 - 12/2004
2	PlectinIBA 04/2004 - 06/2002
1	neonatal Fc receptorIBA 08/2008
1	Azathioprine (Imuran)FDA LinkGeneric 12/2007
1	mycophenolate mofetil (Cellcept)FDA LinkGeneric 12/2007
1	CalciumIBA 11/2006
1	EpitopesIBA 04/2006
1	Clobetasol (Clobetasol Propionate)FDA LinkGeneric 09/2005
1	Dapsone FDA Link 09/2005
1	Collagen Type VIIIBA 03/2005
1	Pancreatic Elastase (Elastase)IBA 12/2004
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2004
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2004
1	Glycoproteins (Glycoprotein)IBA 12/2003
1	TrehaloseIBA 04/2003
1	Serum AlbuminIBA 07/2002
1	DesminIBA 06/2002
1	Immunoglobulins (Immunoglobulin)IBA 01/2002