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Dafang Zhong Selected Research

3-n-butylphthalide (butylphthalide)

4/2014Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1.
5/2013Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards.
2/2013Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation.

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Dafang Zhong Research Topics

Disease

7Neoplasms (Cancer)
08/2014 - 08/2010
3Lung Injury
06/2012 - 03/2010
2Anaphylaxis (Anaphylactic Shock)
11/2014 - 08/2012
2Amebiasis (Amoebiasis)
10/2014 - 06/2014
2Bacterial Infections (Bacterial Infection)
10/2014 - 06/2014
2Brain Ischemia (Cerebral Ischemia)
04/2014 - 02/2013
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
05/2012 - 08/2010
2Hemorrhage
12/2011 - 03/2010
2Cardiovascular Diseases (Cardiovascular Disease)
11/2011 - 08/2006
1Hyperbilirubinemia
11/2015
1Type 2 Diabetes Mellitus (MODY)
11/2015
1Alveolar Soft Part Sarcoma
11/2013
1Fatigue
11/2013
1Hypothyroidism
11/2013
1Stomatitis
11/2013
1Pain (Aches)
11/2013
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
11/2013
1Stroke (Strokes)
05/2013
1Human Influenza (Influenza)
04/2013
1Rhinitis
03/2013
1Asthma (Bronchial Asthma)
03/2013
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
03/2013
1Hepatic Insufficiency
11/2012
1Renal Insufficiency (Renal Failure)
11/2012
1Breast Neoplasms (Breast Cancer)
10/2012
1Colorectal Neoplasms (Colorectal Cancer)
05/2012
1Confusion (Bewilderment)
10/2011
1Vomiting
10/2010
1Sleep Initiation and Maintenance Disorders (Insomnia)
10/2010
1Nausea
10/2010
1Edema
03/2010
1Infection
02/2007
1Tuberculosis (Tuberculoses)
01/2005
1Cough
02/2004

Drug/Important Bio-Agent (IBA)

3morinidazoleIBA
10/2014 - 11/2012
33-n-butylphthalide (butylphthalide)IBA
04/2014 - 02/2013
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2013 - 08/2010
2BilirubinIBA
11/2015 - 11/2013
24-nitroimidazoleIBA
10/2014 - 06/2014
2Phosphotransferases (Kinase)IBA
01/2014 - 04/2013
2TabletsIBA
12/2013 - 08/2010
2dauricineIBA
06/2012 - 03/2010
2Ketoconazole (Nizoral)FDA LinkGeneric
12/2011 - 03/2010
2scutellarinIBA
11/2011 - 08/2006
1GTP-Binding Proteins (G-Protein)IBA
11/2015
1Histamine (Histamine Dihydrochloride)FDA Link
11/2014
1clofarabine (Clolar)FDA Link
08/2014
1triphosphoric acid (triphosphate)IBA
08/2014
1CytochromesIBA
05/2014
1Epoxide HydrolasesIBA
05/2014
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
05/2014
1Epidermal Growth Factor (EGF)IBA
12/2013
1malic acid (malate)IBA
11/2013
1Tyrosine (L-Tyrosine)FDA Link
11/2013
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
11/2013
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
11/2013
1Renal cell carcinoma 1IBA
11/2013
1Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA
11/2013
1tyrosine receptor (receptor, tyrosine)IBA
04/2013
1arbidolIBA
04/2013
1Budesonide (Pulmicort)FDA LinkGeneric
03/2013
1S 6 (S-6)IBA
10/2012
1Multidrug Resistance-Associated ProteinsIBA
10/2012
1Mesylates (Mesylate)IBA
05/2012
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
12/2011
1tetrandrineIBA
12/2011
1AcidsIBA
10/2011
1Fluoxetine (Prozac)FDA LinkGeneric
10/2010
1Fluorouracil (Carac)FDA LinkGeneric
08/2010
1benzamideIBA
08/2010
1Ethidium (Ethidium Bromide)IBA
03/2010
1compound 30IBA
02/2007
1Isoniazid (Ftivazide)FDA LinkGeneric
01/2005
1Ethambutol (Myambutol)FDA LinkGeneric
01/2005
1Citric Acid (Citrate)FDA LinkGeneric
02/2004
1benproperineIBA
02/2004

Therapy/Procedure

3Oral Administration
12/2013 - 08/2010
1Injections
08/2012