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Yihua Zhang Selected Research

3-n-butylphthalide (butylphthalide)

9/2015Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents.
7/2014(S)-ZJM-289 preconditioning induces a late phase protection against nervous injury induced by transient cerebral ischemia and oxygen-glucose deprivation.
4/2013Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents.
12/2012Studies on the enantiomers of ZJM-289: synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities.
8/2012Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.
7/2011Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents.

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Yihua Zhang Research Topics

Disease

17Neoplasms (Cancer)
12/2015 - 08/2008
10Hepatocellular Carcinoma (Hepatoma)
10/2015 - 02/2010
7Stroke (Strokes)
09/2015 - 07/2011
5Alzheimer Disease (Alzheimer's Disease)
04/2014 - 05/2012
4Thrombosis (Thrombus)
08/2014 - 08/2011
2Breast Neoplasms (Breast Cancer)
12/2014 - 08/2014
2Brain Ischemia (Cerebral Ischemia)
07/2014 - 12/2012
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2013 - 07/2010
2Ischemia
08/2012 - 01/2012
2Inflammation
06/2011 - 07/2010
2Carcinoma (Carcinomatosis)
05/2011 - 08/2008
2Atherosclerosis
05/2010 - 11/2004
1Colorectal Neoplasms (Colorectal Cancer)
12/2015
1Colonic Neoplasms (Colon Cancer)
03/2015
1Acute Lung Injury
03/2015
1Infection
03/2015
1Poliomyelitis (Polio)
09/2014
1Transient Ischemic Attack
07/2014
1Lymphoma (Lymphomas)
07/2014
1Hyperglycemia
01/2014
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2014
1Cardiovascular Diseases (Cardiovascular Disease)
11/2012
1Heart Failure
11/2012
1Glioblastoma (Glioblastoma Multiforme)
10/2012
1Stomach Neoplasms (Stomach Cancer)
06/2012
1Food Hypersensitivity (Food Allergy)
06/2011
1Rheumatoid Arthritis
12/2010
1Lewis Lung Carcinoma
07/2010
1Lung Neoplasms (Lung Cancer)
07/2010

Drug/Important Bio-Agent (IBA)

13Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2015 - 08/2008
63-n-butylphthalide (butylphthalide)IBA
09/2015 - 07/2011
6Oleanolic AcidIBA
06/2013 - 08/2008
61,2,5-oxadiazole 2-oxideIBA
06/2013 - 08/2008
4P-GlycoproteinIBA
12/2014 - 04/2012
4sorafenib (BAY 43-9006)FDA Link
07/2014 - 05/2010
3Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
08/2014 - 08/2011
3Glucose (Dextrose)FDA LinkGeneric
07/2014 - 01/2012
3Tacrine (Cognex)FDA Link
12/2013 - 05/2013
3Flurbiprofen (Froben)FDA LinkGeneric
12/2013 - 05/2013
3farnesylthiosalicylic acidIBA
06/2011 - 05/2010
2Caspase 3 (Caspase-3)IBA
12/2015 - 02/2015
2Histone Deacetylases (Histone Deacetylase)IBA
12/2015 - 06/2015
2phenylmethylpyrazoloneIBA
09/2015 - 08/2012
2methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oateIBA
03/2015 - 03/2015
2Epinephrine (Adrenaline)FDA LinkGeneric
08/2014 - 08/2011
2CollagenIBA
08/2014 - 08/2011
2OxygenIBA
07/2014 - 01/2012
2Cytochromes c (Cytochrome c)IBA
07/2014 - 01/2014
2Arachidonic Acid (Vitamin F)IBA
08/2012 - 07/2010
2oridoninIBA
06/2012 - 01/2012
1ZincIBA
06/2015
1benzamideIBA
06/2015
1Trientine (Trien)FDA Link
06/2015
1Nitric AcidIBA
03/2015
1Antineoplastic Agents (Antineoplastics)IBA
03/2015
1CytokinesIBA
03/2015
1cinnamic acidIBA
02/2015
1ferulic acid (sodium ferulate)IBA
02/2015
1Chalcone (Benzalacetophenone)IBA
12/2014
1bifendateIBA
12/2014
1VaccinesIBA
09/2014
1Neutralizing AntibodiesIBA
09/2014
1diphenyl (biphenyl)IBA
08/2014
1IgA receptor (protein B)IBA
07/2014
1LigasesIBA
06/2014
1UbiquitinIBA
06/2014
1Proteins (Proteins, Gene)IBA
06/2014
1carbazoleIBA
04/2014
1dibenzofuranIBA
04/2014
1Galantamine (Galanthamine)FDA LinkGeneric
04/2014
1Insulin (Novolin)FDA Link
01/2014
1Streptozocin (Streptozotocin)FDA Link
01/2014
1C-PeptideIBA
01/2014
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
06/2013
1Glutathione Transferase (Glutathione S-Transferase)IBA
06/2013
1ProdrugsIBA
06/2013
1IsosorbideFDA Link
04/2013
1Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
04/2013
11-isopropyldiazen-1-ium-1,2-diolateIBA
11/2012
1Peptide Initiation Factors (Initiation Factor)IBA
10/2012
1O(2)- (2,4- dinitro- 5- (N- methyl- N- 4- carboxyphenylamino)phenyl 1- N,N- dimethylamino)diazen- 1- ium- 1,2- diolateIBA
09/2012
1Fibrinolytic Agents (Antithrombotic Agents)IBA
08/2012
1Adenosine Diphosphate (ADP)IBA
08/2012
1EnzymesIBA
08/2012
1diazeniumdiolateIBA
05/2012
1AcetylcholinesteraseIBA
05/2012
1gambogic acidIBA
01/2012
1Cholinergic Antagonists (Anticholinergics)IBA
06/2011
1AntigensIBA
06/2011
1Immunoglobulin E (IgE)IBA
06/2011
1Indicators and Reagents (Reagents)IBA
12/2010
1Glycyrrhetinic Acid (Po 12)IBA
11/2010
1CI 1004IBA
07/2010
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
07/2010
1Hemoglobins (Hemoglobin)IBA
05/2010

Therapy/Procedure

3Drug Therapy (Chemotherapy)
05/2012 - 07/2010
2Heterologous Transplantation (Xenotransplantation)
01/2014 - 06/2013
1Oral Administration
12/2012
1Therapeutics
05/2012
1Chemoprevention
07/2010