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Guang-Yi Zhang Selected Research

Brain Ischemia (Cerebral Ischemia)

5/2012Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic neuronal injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA(A) receptors.
1/2012S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia.
1/2012N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity.
8/2011K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
4/2010Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia.
1/2010Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia.
12/2009Inhibition of cerebral ischemia/reperfusion-induced injury by adenovirus expressed C-terminal amino acids of GluR6.
12/2009Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6.PSD-95.MLK3 pathway.
11/2009Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction.
6/2009Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation.
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Guang-Yi Zhang Research Topics

Disease

56Brain Ischemia (Cerebral Ischemia)
05/2012 - 11/2002
51Ischemia
01/2012 - 04/2003
18Brain Injuries (Brain Injury)
04/2012 - 02/2005
7Transient Ischemic Attack
06/2012 - 08/2004
5Seizures (Seizure)
09/2012 - 02/2006
3Stroke (Strokes)
12/2009 - 02/2007
2Epilepsy (Aura)
03/2011 - 06/2006
1Neuroblastoma
03/2011
1B-Cell Lymphoma (Lymphoma, B Cell)
03/2011
1Infection
12/2008
1Hypothermia
01/2008

Drug/Important Bio-Agent (IBA)

25N-Methylaspartate (NMDA)IBA
06/2012 - 11/2002
19glucuronyl glucosamine glycan sulfate (Vessel)IBA
06/2008 - 11/2002
13Tyrosine (L-Tyrosine)FDA Link
06/2012 - 05/2003
13Phosphotransferases (Kinase)IBA
12/2009 - 04/2003
11JNK Mitogen-Activated Protein KinasesIBA
04/2012 - 02/2005
11postsynaptic density proteinsIBA
12/2009 - 06/2003
9Kainic Acid (Kainate)IBA
09/2012 - 12/2005
8mitogen-activated protein kinase kinase kinase 11IBA
01/2012 - 05/2005
7Glutamate Receptors (Glutamate Receptor)IBA
04/2012 - 06/2005
6OligodeoxyribonucleotidesIBA
01/2012 - 01/2004
6Serine (L-Serine)FDA Link
09/2007 - 01/2004
6Calcium Channels (Calcium Channel)IBA
05/2006 - 11/2002
5GABA Receptors (GABA Receptor)IBA
09/2012 - 04/2008
5Kainic Acid Receptors (Kainate Receptor)IBA
05/2012 - 12/2005
5Cytochromes c (Cytochrome c)IBA
08/2011 - 04/2004
5KetamineFDA LinkGeneric
01/2009 - 04/2003
5N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10/2008 - 11/2002
5Acetylcysteine (Siran)FDA LinkGeneric
11/2006 - 06/2003
5Nifedipine (Adalat)FDA LinkGeneric
05/2005 - 05/2003
4Carbon MonoxideIBA
09/2012 - 11/2002
4Caspase 3 (Caspase-3)IBA
09/2012 - 05/2006
4CalciumIBA
01/2012 - 01/2004
4anthra(1,9-cd)pyrazol-6(2H)-oneIBA
11/2011 - 02/2005
4gamma-Aminobutyric Acid (GABA)IBA
10/2008 - 04/2008
4Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
11/2005 - 01/2004
4OligonucleotidesIBA
09/2005 - 06/2003
4salicylhydroxamic acid (SHAM)IBA
11/2003 - 11/2002
3Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
01/2012 - 01/2004
3alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
01/2010 - 11/2005
3AMPA Receptors (AMPA Receptor)IBA
01/2010 - 01/2004
3OxygenIBA
12/2009 - 04/2008
3Glucose (Dextrose)FDA LinkGeneric
12/2009 - 04/2008
3Protein Kinases (Protein Kinase)IBA
11/2009 - 04/2004
3BaclofenFDA LinkGeneric
10/2008 - 04/2008
3MuscimolIBA
10/2008 - 04/2008
3Proteins (Proteins, Gene)IBA
09/2007 - 11/2003
3FG 9041 (DNQX)IBA
11/2005 - 04/2003
3Antisense OligonucleotidesIBA
05/2005 - 06/2003
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2004 - 06/2003
2Mitogen-Activated Protein Kinase 10IBA
05/2012 - 09/2006
2Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
01/2012 - 08/2008
2Dizocilpine Maleate (Dizocilpine)IBA
01/2012 - 06/2008
214-3-3 Proteins (14-3-3 Protein)IBA
08/2011 - 09/2007
2Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2010 - 01/2007
2tat Gene Products (tat Protein)IBA
08/2009 - 02/2006
2Ionotropic Glutamate ReceptorsIBA
10/2008 - 05/2006
2GABA-B Receptor AgonistsIBA
10/2008 - 06/2008
2GABA-A Receptor AgonistsIBA
10/2008 - 06/2008
2GABA-B Receptors (Receptor, GABA-B)IBA
06/2008 - 04/2008
2Glutamic Acid (Glutamate)FDA Link
04/2008 - 11/2005
2ligustilideIBA
01/2008 - 02/2007
2Calmodulin (Calcium-Dependent Activator Protein)IBA
01/2007 - 01/2004
2MAP Kinase Kinase 4IBA
12/2006 - 07/2006
2Fas Ligand Protein (Fas Ligand)IBA
12/2006 - 09/2006
2Dihydrotachysterol (AT 10)IBA
11/2006 - 06/2003
2Vanadates (Orthovanadate)IBA
08/2006 - 06/2003
2SodiumIBA
08/2006 - 06/2003
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2006 - 12/2005
2Dextromethorphan (Levomethorphan)FDA LinkGeneric
05/2005 - 01/2004
2LithiumIBA
08/2004 - 09/2003
2GenisteinIBA
11/2003 - 06/2003
2NF-kappa B (NF-kB)IBA
11/2003 - 04/2003
2DNA (Deoxyribonucleic Acid)IBA
11/2003 - 06/2003
1S-NitrosoglutathioneIBA
01/2012
17-nitroindazoleIBA
01/2012
1Nitric Oxide Synthase (NO Synthase)IBA
01/2012
1ThioredoxinsIBA
01/2012
1K 252 (K252a)IBA
08/2011
1Small Interfering RNA (siRNA)IBA
03/2011
1Amino AcidsFDA Link
12/2009
1Gluk2 kainate receptorIBA
12/2009
1Ethanol (Ethyl Alcohol)IBA
06/2009
1cresyl violetIBA
06/2009
1p38 Mitogen-Activated Protein KinasesIBA
01/2009
1MAP-kinase-activated kinase 2IBA
01/2009
1DAPIIBA
12/2008
1GABA Agonists (GABA Receptor Agonists)IBA
10/2008
1CalcineurinIBA
10/2008
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2008
1pyrimidineIBA
06/2008
1Butyric Acid (Butanoic Acid)IBA
04/2008
1GABA-A Receptors (GABA(A) Receptor)IBA
04/2008
1phthalideIBA
01/2008
1Transcription Factors (Transcription Factor)IBA
01/2008
1src-Family KinasesIBA
06/2007
1Eosine Yellowish-(YS) (Eosin)IBA
06/2007
1Hematoxylin (Haematoxylon)IBA
06/2007

Therapy/Procedure

5Intraventricular Infusions
12/2005 - 06/2003
1Therapeutics
10/2007