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Takehiko Yokomizo Selected Research

Leukotriene B4

1/2015The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.
1/2015The role of leukotrienes in allergic diseases.
8/2013Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment.
1/2013Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma.
10/2012Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems.
5/2010The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury.
8/2008Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells.
7/2008Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin.
2/2007Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation.
10/2005Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses.
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Takehiko Yokomizo Research Topics

Disease

13Inflammation
12/2015 - 08/2002
3Asthma (Bronchial Asthma)
08/2013 - 10/2005
3Neoplasms (Cancer)
10/2012 - 12/2005
2Colitis
02/2015 - 12/2010
2Eosinophilia
08/2013 - 01/2013
1Nausea
12/2015
1Vomiting
12/2015
1Chronic Obstructive Pulmonary Disease (COPD)
12/2015
1Pneumonia (Pneumonitis)
12/2015
1Contact Dermatitis (Eczema, Contact)
10/2015
1Pain (Aches)
01/2015
1Airway Remodeling
01/2015
1Autoimmune Diseases (Autoimmune Disease)
12/2014
1Relapsing-Remitting Multiple Sclerosis
12/2014
1Wounds and Injuries (Trauma)
06/2014
1Lichen Planus (Lichen Ruber Planus)
03/2014
1Psoriasis (Pustulosis Palmaris et Plantaris)
03/2014
1Eczema
03/2014
1Reperfusion Injury
08/2013
1Ischemia
08/2013
1Hemorrhage
04/2013
1Edema
04/2013
1Leukemia
10/2012
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2010
1Hypersensitivity (Allergy)
06/2010
1Spinal Cord Injuries (Spinal Cord Injury)
05/2010
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
04/2010
1Bone Resorption
12/2009
1Pancreatic Neoplasms (Pancreatic Cancer)
08/2008
1Endotoxemia
07/2008
1Fibrosis (Cirrhosis)
05/2006
1Immune System Diseases (Immune Disorders)
10/2005
1Infection
07/2003
1Insulin Resistance
06/2003
1Obesity
06/2003
1Chronic Kidney Failure (Chronic Renal Failure)
10/2002

Drug/Important Bio-Agent (IBA)

12Leukotriene B4IBA
01/2015 - 08/2002
7Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA
01/2015 - 10/2005
3GTP-Binding Proteins (G-Protein)IBA
12/2014 - 07/2003
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 05/2006
2CytokinesIBA
12/2015 - 06/2010
1Type 4 Cyclic Nucleotide PhosphodiesterasesIBA
12/2015
1Phosphodiesterase 4 InhibitorsIBA
12/2015
1ChemokinesIBA
12/2015
1LeukotrienesIBA
12/2015
15S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acidIBA
10/2015
1Dextran SulfateIBA
02/2015
1Bronchoconstrictor AgentsIBA
01/2015
1Formaldehyde (Formol)FDA Link
01/2015
1Lysosphingolipid ReceptorsIBA
12/2014
1fingolimod (FTY720)FDA Link
12/2014
1lipoxin A4IBA
08/2014
112-hydroxy-5,8,10-heptadecatrienoic acidIBA
06/2014
1Matrix MetalloproteinasesIBA
06/2014
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
06/2014
1involucrinIBA
03/2014
1OvalbuminIBA
08/2013
1Messenger RNA (mRNA)IBA
08/2013
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
04/2013
1Double-Stranded RNA (RNA, Double Stranded)IBA
01/2013
1Prostaglandin D2IBA
01/2013
1Interleukin-13IBA
01/2013
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
10/2012
1AntigensIBA
10/2012
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
12/2010
1Substance PIBA
12/2010
1matrigelIBA
12/2010
1Dextrans (Dextran)FDA Link
12/2010
1benzofuranIBA
08/2008
1CalciumIBA
08/2008
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
07/2008
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
02/2007
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
05/2006
1Platelet Activating FactorIBA
05/2006
14-hydroxy-2-hexenalIBA
05/2006
1Folic Acid (Vitamin M)FDA LinkGeneric
05/2006
1ezrinIBA
12/2005
1S100 Proteins (S 100 Protein)IBA
12/2005
1Carbon MonoxideIBA
07/2003
1AdiponectinIBA
06/2003
1Glucose (Dextrose)FDA LinkGeneric
06/2003
1Nitric Oxide Synthase (NO Synthase)IBA
10/2002

Therapy/Procedure

1Injections
01/2015
1Transplantation (Transplant Recipients)
04/2013
1Ovariectomy (Oophorectomy)
12/2009