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Hitoshi Yamauchi Selected Research

Ketoprofen (Orudis)

3/2010Photoinflammatory responses to UV-irradiated ketoprofen mediated by the induction of ROS generation, enhancement of cyclooxygenase-2 expression, and regulation of multiple signaling pathways.
10/2008Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in rats.
12/2007Molecular response to phototoxic stress of UVB-irradiated ketoprofen through arresting cell cycle in G2/M phase and inducing apoptosis.
2/2005Phototoxicity study of a ketoprofen poultice in guinea pigs.

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Hitoshi Yamauchi Research Topics

Disease

3Prostatic Neoplasms (Prostate Cancer)
04/2010 - 12/2006
2Skin Diseases
03/2010 - 12/2007
2Phototoxic Dermatitis (Phototoxicity)
12/2007 - 02/2005
2Aneurysm (Aneurysms)
05/2007 - 08/2004
2Coronary Aneurysm (Aneurysm, Coronary)
05/2007 - 08/2004
1Thrombosis (Thrombus)
06/2010
1Venous Thrombosis (Deep-Vein Thrombosis)
06/2010
1Inflammation
03/2010
1Neoplasms (Cancer)
12/2009
1Melanoma (Melanoma, Malignant)
12/2009
1Arthritis (Polyarthritis)
10/2008
1Osteoarthritis
01/2008
1Pain (Aches)
01/2008
1Carcinoma (Carcinomatosis)
12/2006
1Dermatitis
02/2005
1Myocardial Ischemia (Ischemic Heart Diseases)
08/2004
1Myocardial Infarction
08/2004
1Atrial Heart Septal Defects (Atrial Septal Defect)
04/2004
1Vascular Diseases (Vascular Disease)
04/2004
1Pulmonary Hypertension (Ayerza Syndrome)
04/2004
1Pathologic Constriction (Stenosis)
06/2003
1Alagille Syndrome
06/2003
1Congenital Abnormalities (Deformity)
01/2003
1Mitral Valve Insufficiency (Mitral Regurgitation)
01/2003

Drug/Important Bio-Agent (IBA)

4Ketoprofen (Orudis)FDA LinkGeneric
03/2010 - 02/2005
3Androgen Receptors (Androgen Receptor)IBA
04/2010 - 12/2006
2DNA (Deoxyribonucleic Acid)IBA
01/2010 - 12/2009
2beta-thujaplicinIBA
12/2009 - 12/2006
2Iodoacetates (Iodoacetate)IBA
10/2008 - 01/2008
1CamptothecinIBA
04/2010
1Type I DNA Topoisomerases (Topoisomerase I)IBA
04/2010
1Reactive Oxygen Species (Oxygen Radicals)IBA
03/2010
1Type II DNA Topoisomerases (Topoisomerase II)IBA
01/2010
1Etoposide (VP 16)FDA LinkGeneric
01/2010
1UbiquitinIBA
12/2009
1TropoloneIBA
12/2009
1biphenylylacetic acid (felbinac)IBA
01/2008
1Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
05/2007
1Complementary DNA (cDNA)IBA
05/2007
1Nitric Oxide Synthase (NO Synthase)IBA
05/2007
1beta-Galactosidase (Lactaid)IBA
05/2007
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
05/2007
1Epoprostenol (Prostacyclin)FDA LinkGeneric
04/2004
1Cyclosporine (Ciclosporin)FDA LinkGeneric
06/2003
1Tissue Inhibitor of Metalloproteinases (TIMP)IBA
01/2003

Therapy/Procedure

2Coronary Artery Bypass (Coronary Artery Bypass Surgery)
05/2007 - 08/2004
1Thrombectomy
06/2010
1Transplants (Transplant)
08/2004
1Liver Transplantation
06/2003