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John J Wright Selected Research

sorafenib (BAY 43-9006)

9/2015A Phase II Study of Sorafenib Combined With Cetuximab in EGFR-Expressing, KRAS-Mutated Metastatic Colorectal Cancer.
8/2014Randomized phase II trial of sorafenib alone or in combination with carboplatin/paclitaxel in women with recurrent platinum sensitive epithelial ovarian, peritoneal, or fallopian tube cancer.
5/2013Phase II trial of sorafenib in patients with advanced anaplastic carcinoma of the thyroid.
4/2013Phase I pharmacokinetic and pharmacodynamic study of cetuximab, irinotecan and sorafenib in advanced colorectal cancer.
12/2012Plasma protein binding of sorafenib, a multi kinase inhibitor: in vitro and in cancer patients.
12/2012Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02.
2/2012Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma.
10/2011A phase I trial of sorafenib plus gemcitabine and capecitabine for patients with advanced renal cell carcinoma: New York Cancer Consortium Trial NCI 6981.
10/2011A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium.
3/2011Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib.
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John J Wright Research Topics

Disease

45Neoplasms (Cancer)
10/2015 - 03/2004
12Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2015 - 02/2007
9Prostatic Neoplasms (Prostate Cancer)
05/2012 - 07/2004
8Leukemia
09/2015 - 01/2003
6Adenocarcinoma
06/2014 - 04/2003
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2014 - 05/2003
5Renal Cell Carcinoma (Grawitz Tumor)
04/2013 - 08/2007
5Myelodysplastic Syndromes (Myelodysplastic Syndrome)
03/2011 - 12/2003
4Breast Neoplasms (Breast Cancer)
10/2015 - 07/2006
4Carcinoma (Carcinomatosis)
10/2013 - 03/2004
4Exanthema (Rash)
05/2013 - 01/2008
4Diarrhea
03/2011 - 01/2008
4Hematologic Neoplasms (Hematological Malignancy)
02/2011 - 08/2006
3Neutropenia
05/2012 - 02/2009
3Melanoma (Melanoma, Malignant)
02/2012 - 11/2009
3T-Cell Lymphoma (Lymphoma, T Cell)
06/2011 - 06/2006
3Multiple Myeloma
01/2011 - 05/2004
3Fatigue
05/2010 - 01/2008
2Colorectal Neoplasms (Colorectal Cancer)
09/2015 - 04/2013
2Ovarian Neoplasms (Ovarian Cancer)
08/2014 - 08/2008
2Brain Neoplasms (Brain Tumor)
04/2014 - 12/2012
2Hypertension (High Blood Pressure)
05/2013 - 01/2011
2Head and Neck Neoplasms (Head and Neck Cancer)
12/2012 - 09/2011
2Stomach Neoplasms (Stomach Cancer)
06/2012 - 12/2011
2Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
06/2011 - 06/2006
2Neoplasm Metastasis (Metastasis)
01/2011 - 05/2007
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
08/2010 - 04/2009
2Nausea
05/2010 - 01/2008
2Fever (Fevers)
05/2010 - 01/2008
2Pancreatic Neoplasms (Pancreatic Cancer)
11/2009 - 04/2003
2Waldenstrom Macroglobulinemia (Macroglobulinemia)
03/2009 - 04/2007
1Fallopian Tube Neoplasms
08/2014
1Cholangiocarcinoma
06/2014
1Biliary Tract Neoplasms (Biliary Tract Cancer)
06/2014
1Plexiform Neurofibroma
05/2014
1Neurofibromatosis 1 (Neurofibromatosis Type I)
05/2014
1Glioma (Gliomas)
04/2014
1Pheochromocytoma
04/2013
1Glioblastoma (Glioblastoma Multiforme)
12/2012
1Gliosarcoma
12/2012

Drug/Important Bio-Agent (IBA)

22sorafenib (BAY 43-9006)FDA Link
09/2015 - 08/2007
20bortezomib (Velcade)FDA Link
06/2014 - 04/2005
19tipifarnib (R115777)IBA
05/2014 - 04/2003
11Farnesyltranstransferase (Farnesyltransferase)IBA
05/2014 - 04/2003
8Proteasome Endopeptidase Complex (Proteasome)IBA
06/2014 - 04/2005
8Histone Deacetylase InhibitorsIBA
12/2012 - 06/2006
7flavopiridolIBA
09/2015 - 01/2003
7Cytarabine (Cytosar-U)FDA LinkGeneric
09/2015 - 12/2005
7romidepsin (FK228)FDA Link
12/2012 - 06/2006
7docetaxel (Taxotere)FDA Link
01/2011 - 07/2004
6Mitoxantrone (Novantrone)FDA LinkGeneric
09/2015 - 12/2005
6Thalidomide (Thalomid)FDA Link
04/2010 - 03/2004
5TransferasesIBA
10/2013 - 05/2003
5Phosphotransferases (Kinase)IBA
04/2013 - 06/2008
4Biological Markers (Surrogate Marker)IBA
10/2015 - 04/2009
4erlotinib (CP 358,774)FDA Link
04/2014 - 08/2007
4Prostate-Specific Antigen (Semenogelase)IBA
05/2012 - 01/2008
3cetuximab (Erbitux)FDA Link
09/2015 - 09/2011
3Paclitaxel (Taxol)FDA LinkGeneric
08/2014 - 05/2010
3irinotecan (Camptosar)FDA LinkGeneric
06/2014 - 04/2005
3temsirolimusFDA Link
04/2014 - 02/2012
3vorinostat (suberoylanilide hydroxamic acid)FDA Link
12/2013 - 08/2009
3Doxorubicin (Adriamycin)FDA LinkGeneric
10/2013 - 07/2006
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2013 - 07/2006
3Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2013 - 11/2009
3Etoposide (VP 16)FDA LinkGeneric
01/2012 - 02/2009
3bevacizumabFDA Link
04/2010 - 08/2008
3VA 061 (VA061)IBA
01/2008 - 07/2004
2PlatinumIBA
08/2014 - 02/2007
2Carboplatin (JM8)FDA LinkGeneric
08/2014 - 02/2009
2Sirolimus (Rapamycin)FDA Link
04/2014 - 12/2012
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
04/2014 - 03/2010
2src-Family KinasesIBA
01/2014 - 06/2012
2Filgrastim (Neupogen)FDA Link
10/2013 - 04/2009
2dasatinib (BMS 354825)FDA Link
01/2013 - 03/2011
2TransaminasesIBA
05/2012 - 01/2008
2Proteins (Proteins, Gene)IBA
02/2012 - 04/2003
2Cyclin D1IBA
12/2011 - 01/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2011 - 04/2009
2tranilast (N 5')IBA
05/2010 - 08/2009
2Prednisone (Sone)FDA LinkGeneric
04/2010 - 02/2009
2Interferon Alfa-2b (Interferon Alfa 2b)FDA Link
01/2010 - 08/2007
2lenalidomide (CC 5013)FDA Link
06/2009 - 03/2004
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
04/2009 - 06/2008
2carbazoleIBA
04/2005 - 03/2004
1ARQ 197IBA
10/2015
1Daunorubicin (Cerubidine)FDA LinkGeneric
09/2015
1Estrogens (Estrogen)FDA Link
10/2013
1R788 compoundIBA
04/2013
1Histone Deacetylases (Histone Deacetylase)IBA
12/2012
1Carrier Proteins (Binding Protein)IBA
12/2012
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
12/2012
1tyrosine receptor (receptor, tyrosine)IBA
06/2012
1N- (5- chloro- 1,3- benzodioxol- 4- yl)- 7- (2- (4- methylpiperazin- 1- yl)ethoxy)- 5- (tetrahydro- 2H- pyran- 4- yloxy)quinazolin- 4- amineIBA
06/2012
1Drug CombinationsIBA
06/2012

Therapy/Procedure

11Drug Therapy (Chemotherapy)
10/2015 - 05/2004
5Castration
05/2012 - 02/2009
3Heterologous Transplantation (Xenotransplantation)
04/2005 - 04/2003
1Therapeutics
06/2014
1Molecular Targeted Therapy
12/2012