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Orly Weinreb Selected Research

Monoamine Oxidase (MAO)

3/2015Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.
9/2013Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators.
8/2012Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
4/2012Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment.
3/2011Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.
1/2011A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor.
1/2011Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease.
1/2010Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
11/2009Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.
2/2009The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
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Orly Weinreb Research Topics

Disease

23Neurodegenerative Diseases (Neurodegenerative Disease)
09/2015 - 03/2004
17Parkinson Disease (Parkinson's Disease)
03/2015 - 04/2003
14Alzheimer Disease (Alzheimer's Disease)
02/2014 - 10/2006
9Anoxia (Hypoxia)
02/2014 - 01/2005
8Schizophrenia (Dementia Praecox)
05/2015 - 06/2006
8Dementia (Dementias)
04/2012 - 12/2006
7Neuroblastoma
02/2009 - 05/2003
5Inflammation
01/2012 - 09/2004
5Lewy Body Disease (Lewy Body Dementia)
01/2010 - 10/2006
4Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2012 - 03/2004
2Basal Ganglia Diseases (Basal Ganglia Disease)
04/2012 - 01/2011
2Nervous System Diseases (Neurological Disorders)
10/2008 - 01/2008
2Pheochromocytoma
08/2005 - 09/2004
2Ischemia
04/2005 - 01/2005
2Craniocerebral Trauma (Head Injury)
04/2005 - 01/2005
1Type 2 Diabetes Mellitus (MODY)
12/2014
1Hepatocellular Carcinoma (Hepatoma)
01/2013
1Hallucinations (Hallucination)
01/2013
1Memory Disorders (Memory Loss)
09/2012
1Amyloid Plaque
05/2012
1Gliosis
04/2012
1Mood Disorders (Mood Disorder)
03/2011
1Huntington Disease (Huntington's Disease)
09/2007
1Shock
08/2007
1Parkinsonian Disorders (Parkinsonism)
01/2007
1Chronic Disease (Chronic Diseases)
09/2005
1Reperfusion Injury
03/2004
1Brain Ischemia (Cerebral Ischemia)
03/2004

Drug/Important Bio-Agent (IBA)

23IronIBA
03/2015 - 03/2004
16rasagiline (Azilect)FDA Link
09/2015 - 09/2004
16Monoamine Oxidase (MAO)IBA
03/2015 - 09/2004
10TeaIBA
01/2011 - 05/2003
9(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA
04/2012 - 10/2006
7Antipsychotic Agents (Antipsychotics)IBA
05/2015 - 06/2006
7Reactive Oxygen Species (Oxygen Radicals)IBA
12/2009 - 03/2004
6Cholinesterases (Cholinesterase)IBA
04/2012 - 10/2006
6polyphenolsIBA
01/2012 - 03/2004
6Neuroprotective AgentsIBA
09/2007 - 04/2003
5Chelating AgentsIBA
09/2013 - 09/2004
5propargylamineIBA
01/2010 - 04/2005
4Dopamine (Intropin)FDA LinkGeneric
03/2015 - 04/2003
4Serotonin (5 Hydroxytryptamine)IBA
04/2012 - 06/2006
4AntioxidantsIBA
01/2012 - 05/2003
4Proteins (Proteins, Gene)IBA
08/2008 - 04/2003
3GABA-A Receptors (GABA(A) Receptor)IBA
05/2015 - 06/2011
3Amyloid (Amyloid Fibrils)IBA
09/2012 - 10/2006
3N-propargylIBA
08/2012 - 01/2010
3Carbon MonoxideIBA
04/2012 - 12/2006
3Levodopa (L Dopa)FDA LinkGeneric
11/2010 - 01/2005
3NeurotoxinsIBA
11/2009 - 01/2005
3Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
11/2009 - 09/2008
3Messenger RNA (mRNA)IBA
02/2009 - 08/2005
3Complementary DNA (cDNA)IBA
12/2004 - 04/2003
2Brain-Derived Neurotrophic Factor (BDNF)IBA
05/2015 - 08/2005
2Fluvoxamine (Luvox)FDA LinkGeneric
05/2015 - 06/2011
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
03/2015 - 01/2007
2Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)IBA
01/2014 - 08/2007
2Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
09/2012 - 02/2009
2Oxyquinoline (8 Hydroxyquinoline)FDA Link
08/2012 - 01/2010
2methyl carbamateIBA
04/2012 - 01/2010
2FlavonoidsIBA
01/2012 - 01/2011
2Free RadicalsIBA
01/2012 - 01/2011
2rivastigmine (Exelon)FDA LinkGeneric
01/2010 - 10/2006
2Selegiline (E250)FDA LinkGeneric
01/2010 - 11/2009
2Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
11/2009 - 01/2009
2CatalaseIBA
02/2009 - 09/2008
2Catechin (Z 7300)IBA
10/2008 - 01/2008
1gamma-Aminobutyric Acid (GABA)IBA
05/2015
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2015
1Oxidopamine (6 Hydroxydopamine)IBA
03/2015
1Glucose (Dextrose)FDA LinkGeneric
02/2014
1Insulin (Novolin)FDA Link
02/2014
1Insulin ReceptorIBA
02/2014
1Fructose-Bisphosphate Aldolase (Aldolase)IBA
02/2014
1SynucleinsIBA
09/2013
1Ferritins (Ferritin)IBA
01/2013
1Presenilin-1IBA
09/2012
1Antidepressive Agents (Antidepressants)IBA
04/2012
1Acetylcholine (Acetylcholine Chloride)FDA Link
04/2012
1Streptozocin (Streptozotocin)FDA Link
04/2012
1lactacystinIBA
03/2011
1Biological Markers (Surrogate Marker)IBA
11/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2009
1EnzymesIBA
02/2009
1benzoquinone (quinone)IBA
02/2009
1NAD (NADH)IBA
02/2009
1PeroxiredoxinsIBA
02/2009
1Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
02/2009
1Apoptosis Regulatory ProteinsIBA
09/2007
1Caspase 3 (Caspase-3)IBA
09/2007
1OxygenIBA
08/2007
1Mixed Function Oxygenases (Monooxygenases)IBA
08/2007
1MicronutrientsIBA
09/2005
1CopperIBA
09/2004
1gallocatechol (epigallocatechin)IBA
03/2004
1MelatoninIBA
05/2003
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
05/2003
1ApomorphineIBA
05/2003

Therapy/Procedure

1Therapeutics
03/2011
1Drug Therapy (Chemotherapy)
01/2009