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Paul Webb Selected Research

GC 1 compound

7/2013Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.
12/2012Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor.
1/2012Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1.
1/2008Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
7/2005Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.

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Paul Webb Research Topics

Disease

12Neoplasms (Cancer)
11/2015 - 01/2002
8Prostatic Neoplasms (Prostate Cancer)
01/2015 - 01/2002
7Obesity
08/2015 - 01/2008
6Insulin Resistance
08/2015 - 01/2009
4Dyslipidemias (Dyslipidemia)
11/2013 - 07/2005
4Breast Neoplasms (Breast Cancer)
08/2009 - 01/2002
3Anoxia (Hypoxia)
01/2015 - 04/2008
3Fatty Liver
01/2015 - 12/2010
3Weight Loss (Weight Reduction)
04/2009 - 05/2004
3Body Weight (Weight, Body)
04/2009 - 05/2004
3Hypercholesterolemia
09/2008 - 07/2005
2Weight Gain
08/2015 - 08/2012
2Edema
08/2015 - 08/2012
2Neoplasm Metastasis (Metastasis)
01/2015 - 04/2008
2Androgen-Insensitivity Syndrome (Testicular Feminization)
07/2012 - 10/2007
1Heart Failure
08/2015
1Colorectal Neoplasms (Colorectal Cancer)
02/2015
1Cholangiocarcinoma
01/2015
1Hyperglycemia
07/2013
1Hyperinsulinism (Hyperinsulinemia)
07/2013
1Asymptomatic Infections
01/2013
1Bovine Spongiform Encephalopathy (Mad Cow Disease)
01/2013
1Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
12/2012
1Gallstones (Gallstone)
12/2012
1Liver Diseases (Liver Disease)
12/2012
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Heart Diseases (Heart Disease)
01/2012
1Fibrosis (Cirrhosis)
12/2010
1Atherosclerosis
04/2009
1Tachycardia (Tachyarrhythmias)
09/2008
1Melanoma (Melanoma, Malignant)
04/2008
1Carcinoma (Carcinomatosis)
04/2008
1Lymphatic Metastasis
04/2008
1Glioblastoma (Glioblastoma Multiforme)
04/2008
1Colonic Neoplasms (Colon Cancer)
01/2008
1Scrapie
07/2006
1Chronic Kidney Failure (Chronic Renal Failure)
07/2004
1Osteoporosis
05/2004
1Endocrine System Diseases (Endocrine Diseases)
12/2003
1Hypertrophy
04/2003

Drug/Important Bio-Agent (IBA)

9CholesterolIBA
11/2013 - 05/2004
8HormonesIBA
01/2012 - 04/2003
5GC 1 compoundIBA
07/2013 - 07/2005
4Insulin (Novolin)FDA Link
08/2015 - 08/2012
4Glucose (Dextrose)FDA LinkGeneric
08/2015 - 01/2012
4Non-alcoholic Fatty Liver DiseaseIBA
01/2015 - 12/2010
4Carbon MonoxideIBA
01/2015 - 11/2012
4Androgen Receptors (Androgen Receptor)IBA
01/2015 - 03/2005
4Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA
01/2015 - 09/2008
4Estrogens (Estrogen)FDA Link
01/2015 - 01/2002
4Proteins (Proteins, Gene)IBA
01/2015 - 01/2008
3Triglycerides (Triacylglycerol)IBA
01/2015 - 07/2005
3LigandsIBA
01/2014 - 08/2012
3Molecular Chaperones (Chaperone, Molecular)IBA
11/2012 - 01/2008
23- ((3,5- dibromo- 4- (4- hydroxy- 3- (1- methylethyl)phenoxy)phenyl)amino)- 3- oxopropanoic acidIBA
07/2013 - 12/2012
2rosiglitazone (Avandia)FDA Link
08/2012 - 12/2010
2Thyroid HormonesIBA
04/2009 - 07/2004
2Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2009 - 12/2003
2Triiodothyronine (Liothyronine)FDA LinkGeneric
09/2008 - 04/2003
25- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA
04/2008 - 01/2008
1irinotecan (Camptosar)FDA LinkGeneric
11/2015
1Checkpoint kinase 1IBA
11/2015
1gemcitabineFDA Link
11/2015
1Cell Cycle ProteinsIBA
11/2015
1CamptothecinIBA
11/2015
1DNA (Deoxyribonucleic Acid)IBA
11/2015
1PPAR gammaIBA
08/2015
1ThiazolidinedionesIBA
08/2015
1Calcibiotic Root Canal SealerIBA
02/2015
1tacrolimus binding protein 4 (FKBP52)IBA
01/2015
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2015
1Flutamide (Eulexin)FDA LinkGeneric
01/2015
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2015
1Small Molecule LibrariesIBA
01/2014
1PrionsIBA
01/2013
12,4-thiazolidinedione (thiazolidinedione)IBA
08/2012
1Transcription Factors (Transcription Factor)IBA
01/2012
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2012
1Cyclin-Dependent Kinase 5IBA
01/2012
1LDL Receptors (LDL Receptor)IBA
12/2010
1LipidsIBA
04/2009
1KB 141IBA
09/2008
1Nonesterified Fatty Acids (NEFA)IBA
09/2008
1Heat-Shock Proteins (Heat-Shock Protein)IBA
04/2008
1Cyclin-Dependent Kinase 4IBA
04/2008
1IsoxazolesIBA
04/2008
1Furylfuramide (AF2)IBA
10/2007
1Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugateIBA
07/2006
1PrPSc ProteinsIBA
07/2006
1AndrogensIBA
03/2005
1Lipoprotein(a)IBA
05/2004
1Endothelins (Endothelin)IBA
04/2003
1Brain Natriuretic Peptide (Natrecor)FDA Link
04/2003
1Estrogen Receptor alphaIBA
03/2003

Therapy/Procedure

5Heterologous Transplantation (Xenotransplantation)
11/2015 - 01/2008
3Therapeutics
11/2013 - 12/2003
1Drug Therapy (Chemotherapy)
11/2015
1Castration
01/2015
1Surgical Instruments (Clip)
01/2013
1Renal Dialysis (Hemodialysis)
07/2004