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Mercedes Unzeta Selected Research

Monoamine Oxidase (MAO)

7/2014Neuroprotective effects of the MAO-B inhibitor, PF9601N, in an in vivo model of excitotoxicity.
6/2014Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.
3/2014Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
1/2014Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
6/2013A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.
6/2012Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
9/2011Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.
1/2011Novel MAO-B inhibitors: potential therapeutic use of the selective MAO-B inhibitor PF9601N in Parkinson's disease.
2/2009Monoamine oxidase-B activity is not involved in the neuroinflammatory response elicited by a focal freeze brain injury.
6/2008Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells.
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Mercedes Unzeta Research Topics

Disease

16Alzheimer Disease (Alzheimer's Disease)
04/2015 - 03/2002
7Parkinson Disease (Parkinson's Disease)
07/2014 - 08/2002
5Neurodegenerative Diseases (Neurodegenerative Disease)
07/2014 - 06/2008
3Stroke (Strokes)
01/2014 - 07/2010
2Gliosis
07/2014 - 02/2009
2Hemorrhage
01/2014 - 07/2010
2Nervous System Diseases (Neurological Disorders)
06/2013 - 03/2012
1Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
02/2015
1Hepatic Encephalopathy
07/2014
1Body Weight (Weight, Body)
07/2014
1Acute Liver Failure (Fulminant Hepatic Failure)
07/2014
1Liver Diseases (Liver Disease)
07/2014
1Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
01/2014
1Brain Ischemia (Cerebral Ischemia)
01/2014
1Inflammation
05/2013
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
04/2013
1Multiple Sclerosis
04/2013
1Diabetes Mellitus
10/2012
1Cerebral Hemorrhage
01/2012
1Vascular Diseases (Vascular Disease)
11/2011
1Intracranial Hemorrhages (Intracranial Hemorrhage)
07/2010
1Brain Injuries (Brain Injury)
02/2009
1Dementia (Dementias)
08/2005
1Neuroblastoma
12/2004
1Parkinsonian Disorders (Parkinsonism)
08/2002
1CADASIL
03/2002

Drug/Important Bio-Agent (IBA)

13Monoamine Oxidase (MAO)IBA
07/2014 - 08/2002
6Cholinesterases (Cholinesterase)IBA
06/2014 - 12/2011
6human AOC3 proteinIBA
01/2014 - 07/2010
5N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamineIBA
07/2014 - 12/2004
5Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
06/2014 - 12/2011
4donepezil (Aricept)FDA LinkGeneric
06/2014 - 12/2011
3EnzymesIBA
04/2015 - 06/2012
3Dopamine (Intropin)FDA LinkGeneric
04/2015 - 12/2004
3Amine Oxidase (Copper-Containing)IBA
02/2015 - 03/2002
3OxidoreductasesIBA
06/2014 - 06/2012
2methylamine (methylammonium)IBA
07/2014 - 06/2008
2propargylamineIBA
06/2014 - 06/2013
2AminesIBA
03/2014 - 06/2012
2Tissue Plasminogen Activator (Alteplase)FDA Link
01/2014 - 07/2010
2Cholinesterase Inhibitors (Anticholinesterases)IBA
06/2012 - 09/2011
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
02/2003 - 08/2002
1Acetylcholine (Acetylcholine Chloride)FDA Link
04/2015
1TheobromineIBA
04/2015
1Kainic Acid (Kainate)IBA
07/2014
1Urea (Carbamide)FDA LinkGeneric
07/2014
1Chelating AgentsIBA
06/2014
1Oxyquinoline (8 Hydroxyquinoline)FDA Link
06/2014
1AmidesIBA
03/2014
1Glucose (Dextrose)FDA LinkGeneric
01/2014
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2014
1OxygenIBA
01/2014
1LigandsIBA
06/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2013
1InterleukinsIBA
04/2013
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
03/2012
1polyphenolsIBA
03/2012
1tranilast (N 5')IBA
12/2011
1Fibrinolytic Agents (Antithrombotic Agents)IBA
07/2010
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2009
1amyloid beta-protein (1-42)IBA
01/2009
1Amphetamine (Amfetamine)FDA LinkGeneric
06/2008
11-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA
06/2008
1amyloid beta-protein (40-42)IBA
08/2005
1Amyloid (Amyloid Fibrils)IBA
08/2005
1Neuroprotective AgentsIBA
12/2004
1Selegiline (E250)FDA LinkGeneric
08/2002

Therapy/Procedure

1Surgical Portacaval Shunt (Portacaval Anastomosis)
07/2014
1Transplantation (Transplant Recipients)
07/2014
1Transplants (Transplant)
07/2014