Kohjiro Ueki Selected Research

Insulin Resistance

07/2008	Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.
04/2007	The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
01/2007	Adiponectin and adiponectin receptors in obesity-linked insulin resistance.
09/2006	Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.
07/2006	Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
04/2006	Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
03/2006	Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
03/2006	Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
07/2004	Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
06/2004	Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.

10	Insulin Resistance 07/2008 - 06/2004
3	Obesity 01/2007 - 07/2002
2	Syndrome 07/2006 - 07/2004
1	Ischemia 04/2006
1	Hyperglycemia 05/2005
1	Lipodystrophy 02/2004
1	Lung Neoplasms (Lung Cancer) 06/2003
1	Hyperinsulinism (Hyperinsulinemia) 06/2003
1	Glucose Intolerance 07/2002
1	Retinal Neovascularization 01/2002

4	AdiponectinIBA 07/2008 - 03/2006
4	Insulin ReceptorIBA 04/2006 - 07/2002
2	Adiponectin ReceptorsIBA 01/2007 - 07/2006
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2006 - 01/2002
2	protein kinase C betaIBA 03/2006 - 01/2002
1	JNK Mitogen-Activated Protein KinasesIBA 04/2007
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2006
1	pioglitazone (Actos)FDA Link 03/2006
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 03/2006
1	Insulin (Novolin)FDA Link 05/2005
1	Suppressor of Cytokine Signaling ProteinsIBA 07/2004
1	Proteins (Proteins, Gene)IBA 06/2004
1	Tyrosine (L-Tyrosine)FDA Link 06/2004
1	LeptinIBA 02/2004
1	Phosphatidylinositols (Phosphatidylinositol)IBA 06/2003
1	MAP Kinase Kinase 4IBA 06/2003
1	Phosphotransferases (Kinase)IBA 06/2003
1	Retinoblastoma ProteinIBA 01/2002