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Hiroyuki Tsuchiya Selected Research

Caffeine (No Doz)

11/2013Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy.
2/2013Caffeine-potentiated chemotherapy for clear cell sarcoma: a report of five cases.
9/2012Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways.
8/2011Caffeine activates tumor suppressor PTEN in sarcoma cells.
7/2011High-grade undifferentiated pleomorphic sarcoma of pelvis treated with curettage and bone graft after complete remission following caffeine-potentiated chemotherapy.
1/2011Potentiation of the antitumor effect of calcium phosphate cement containing anticancer drug and caffeine on rat osteosarcoma.
9/2009Caffeine-potentiated chemotherapy for metastatic osteosarcoma.
5/2009Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma.
5/2008The antitumor effect of liposome-encapsulated cisplatin on rat osteosarcoma and its enhancement by caffeine.
5/2008Caffeine dose-dependently potentiates the antitumor effect of cisplatin on osteosarcomas.
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Hiroyuki Tsuchiya Research Topics

Disease

97Neoplasms (Cancer)
01/2016 - 08/2002
39Osteosarcoma (Osteogenic Sarcoma)
01/2016 - 07/2002
30Neoplasm Metastasis (Metastasis)
10/2015 - 08/2002
17Congenital Abnormalities (Deformity)
06/2015 - 09/2002
16Sarcoma (Soft Tissue Sarcoma)
06/2015 - 01/2003
13Fibrosarcoma
06/2013 - 01/2003
12Infection
01/2015 - 01/2003
7Insulin Resistance
05/2014 - 01/2011
6Pain (Aches)
08/2014 - 04/2006
4Wounds and Injuries (Trauma)
01/2014 - 07/2009
4Hepatocellular Carcinoma (Hepatoma)
11/2013 - 01/2009
4Pancreatic Neoplasms (Pancreatic Cancer)
11/2013 - 06/2009
4Necrosis
05/2013 - 11/2002
4Iron Overload
01/2013 - 12/2010
3Osteomyelitis
10/2014 - 01/2003
3Inflammation
05/2014 - 11/2002
3Thyroid Neoplasms (Thyroid Cancer)
05/2014 - 02/2011
3Liver Neoplasms (Liver Cancer)
10/2013 - 12/2006
3Dislocations
03/2013 - 10/2006
3Fatty Liver
01/2013 - 01/2011
3Liver Diseases (Liver Disease)
06/2010 - 12/2006
2Bone Cysts (Bone Cyst)
06/2015 - 07/2002
2Spinal Stenosis (Stenosis, Spinal)
03/2015 - 02/2013
2Giant Cell Tumors (Giant Cell Tumor)
01/2015 - 09/2006
2Fibrosis (Cirrhosis)
01/2015 - 12/2006
2Arthritis (Polyarthritis)
01/2015 - 10/2014
2Contracture
01/2015 - 01/2003
2Cicatrix (Scar)
01/2015 - 09/2011
2Synovial Sarcoma (Synovioma)
06/2014 - 09/2012
2Glioma (Gliomas)
01/2014 - 04/2011
2Colorectal Neoplasms (Colorectal Cancer)
08/2013 - 02/2008
2Carcinoma (Carcinomatosis)
02/2011 - 05/2005
2Adenocarcinoma
12/2008 - 02/2008
2Chondroma (Enchondroma)
09/2007 - 06/2007
2Lymphoma (Lymphomas)
07/2005 - 05/2005

Drug/Important Bio-Agent (IBA)

21red fluorescent proteinIBA
12/2014 - 01/2003
17NitrogenIBA
12/2015 - 01/2003
15Caffeine (No Doz)FDA LinkGeneric
11/2013 - 11/2002
9TESIBA
10/2015 - 02/2011
8Cisplatin (Platino)FDA LinkGeneric
01/2015 - 11/2002
5Doxorubicin (Adriamycin)FDA LinkGeneric
06/2015 - 11/2002
5TitaniumIBA
01/2015 - 10/2009
5IodineIBA
01/2015 - 09/2012
5Non-alcoholic Fatty Liver DiseaseIBA
01/2013 - 06/2010
5RetinoidsIBA
10/2012 - 12/2006
5Histones (Histone)IBA
01/2012 - 06/2004
4Carrier Proteins (Binding Protein)IBA
04/2015 - 12/2008
4Messenger RNA (mRNA)IBA
11/2013 - 02/2008
4Proteins (Proteins, Gene)IBA
04/2013 - 11/2004
4nestin (nestin protein)IBA
01/2013 - 03/2007
4IronIBA
01/2013 - 01/2009
4ThioredoxinsIBA
05/2011 - 03/2006
4Reactive Oxygen Species (Oxygen Radicals)IBA
12/2010 - 05/2007
3Insulin (Novolin)FDA Link
01/2013 - 01/2012
3FructoseIBA
01/2013 - 01/2012
3Am 80 (tamibarotene)IBA
01/2013 - 01/2012
3Complementary DNA (cDNA)IBA
03/2008 - 01/2007
3DNA (Deoxyribonucleic Acid)IBA
02/2008 - 11/2003
2IfosfamideFDA LinkGeneric
06/2015 - 11/2013
2Ethanol (Ethyl Alcohol)IBA
05/2015 - 09/2006
2Eosine Yellowish-(YS) (Eosin)IBA
06/2014 - 12/2012
2Hematoxylin (Haematoxylon)IBA
06/2014 - 12/2012
2Sirolimus (Rapamycin)FDA Link
01/2014 - 09/2012
2Tretinoin (Retinoic Acid)FDA LinkGeneric
11/2013 - 01/2013
2advanced glycosylation end-product receptorIBA
06/2013 - 06/2007
2Advanced Glycosylation End ProductsIBA
06/2013 - 01/2013
2HMGB1 Protein (HMG1)IBA
06/2013 - 06/2007
2glucuronyl glucosamine glycan sulfate (Vessel)IBA
01/2013 - 04/2006
2Fluorouracil (Carac)FDA LinkGeneric
01/2013 - 09/2009
2LeptinIBA
10/2012 - 01/2012
2Interferon-gamma (Interferon, gamma)IBA
09/2011 - 05/2010
2tensins (tensin)IBA
08/2011 - 06/2011
2Carbon MonoxideIBA
10/2009 - 05/2008
2Alanine Transaminase (SGPT)IBA
05/2009 - 03/2006
2Glutathione (Reduced Glutathione)IBA
02/2008 - 03/2006
2Telomerase (Telomerase Reverse Transcriptase)IBA
11/2007 - 06/2004
28-hydroxy-2'-deoxyguanosineIBA
09/2007 - 03/2006
23,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA
05/2007 - 12/2006

Therapy/Procedure

41Drug Therapy (Chemotherapy)
01/2016 - 08/2002
11Distraction Osteogenesis
08/2014 - 07/2002
9Curettage
06/2015 - 07/2002
8Osteotomy
01/2015 - 09/2002
8Arthroplasty
01/2015 - 05/2010
7External Fixators
03/2014 - 09/2005
6Radiotherapy
01/2015 - 02/2007
5Decompression
12/2015 - 07/2002
5Immunotherapy
08/2012 - 05/2010
4Transplants (Transplant)
08/2014 - 07/2011
4Ilizarov Technique
01/2004 - 09/2002
3Spinal Fusion (Spondylosyndesis)
06/2015 - 09/2013
3Arthrodesis
01/2015 - 01/2003
3Amputation
11/2013 - 10/2011
3Lasers (Laser)
08/2013 - 01/2007
2Transplantation (Transplant Recipients)
12/2015 - 01/2011
2Prostheses and Implants (Prosthesis)
10/2015 - 09/2012
2Catheters
01/2015 - 11/2002
2Cryosurgery
08/2014 - 04/2011
2Palliative Care (Palliative Medicine)
09/2012 - 04/2006
2Limb Salvage
05/2010 - 05/2010
2Bone Transplantation (Bone Grafting)
09/2006 - 01/2003