John Q Trojanowski Selected Research

Dementia (Dementias)

07/2008	Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
01/2008	Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
01/2008	Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
10/2007	TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
10/2007	TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis.
07/2007	TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease.
07/2007	TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
05/2007	Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
04/2007	Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual.
03/2007	TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
10/2006	Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
10/2006	Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies.
03/2004	17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.
03/2004	Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches.
12/2003	Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
05/2003	Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.
05/2002	Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.

Articles by Research Topic

Disease

17	Dementia (Dementias) 07/2008 - 05/2002
8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 07/2008 - 03/2004
8	Alzheimer Disease (Alzheimer's Disease) 06/2008 - 10/2002
7	Tauopathies 06/2008 - 06/2002
7	Brain Injuries (Brain Injury) 12/2007 - 04/2003
6	Parkinson Disease (Parkinson's Disease) 05/2008 - 02/2002
5	Amyloidosis 01/2008 - 07/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2007 - 03/2004
2	Parkinsonian Disorders (Parkinsonism) 01/2008 - 05/2002
2	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2008 - 07/2007
2	Multiple System Atrophy 03/2005 - 03/2004
2	Cytomegalovirus Infections (Inclusion Disease) 09/2004 - 06/2004
2	Pick Disease of the Brain (Pick's Disease) 10/2002 - 06/2002
1	Tremor (Tremors) 05/2006
1	Renal Cell Carcinoma (Grawitz Tumor) 05/2005
1	Hemangioblastoma 05/2005
1	Medulloblastoma 08/2003
1	Neoplasms (Cancer) 08/2003
1	Macular Degeneration (Age-Related Maculopathy) 05/2003
1	Brain Diseases (Brain Disorder) 07/2002
1	Movement Disorders (Movement Disorder) 05/2002
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 05/2002
1	Stroke (Strokes) 04/2002

Drug/Important Bio-Agent (IBA)

12	protein TDP-43IBA 05/2008 - 10/2006
10	alpha-SynucleinIBA 10/2006 - 02/2002
5	tau Proteins (tau Protein)IBA 04/2007 - 10/2002
5	Amyloid (Amyloid Fibrils)IBA 08/2004 - 05/2003
4	UbiquitinIBA 10/2007 - 10/2006
2	alpha-internexinIBA 09/2004 - 06/2004
2	Vitamin E FDA Link 08/2004 - 02/2004
2	Biological Markers (Surrogate Marker)IBA 12/2003 - 07/2003
1	DNA (Deoxyribonucleic Acid)IBA 07/2008
1	DNA-Binding Proteins (DNA Binding Protein)IBA 06/2008
1	Dopamine (Intropin)FDA LinkGeneric 05/2008
1	Proteins (Proteins, Gene)IBA 12/2007
1	Paclitaxel (Taxol)FDA LinkGeneric 07/2007
1	CarbamatesIBA 07/2007
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 05/2007
1	Monoclonal AntibodiesIBA 10/2006
1	pantothenate kinaseIBA 05/2006
1	IronIBA 05/2006
1	LithiumIBA 12/2005
1	AntigensIBA 05/2005
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2005
1	Nerve Growth Factor (NGF)IBA 12/2004
1	NF-kappa B (NF-kB)IBA 12/2004
1	Indomethacin (Indometacin)FDA LinkGeneric 12/2004
1	Caspase 3 (Caspase-3)IBA 08/2004
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 08/2004
1	Presenilin-1IBA 08/2004
1	alpha-Tocopherol FDA Link 07/2004
1	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 05/2004
1	Levodopa (L Dopa)FDA LinkGeneric 03/2004
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2004
1	Crystallins (Crystallin)IBA 01/2004
1	gamma-Synuclein (Persyn)IBA 08/2003
1	RotenoneIBA 01/2003
1	AluminumIBA 07/2002
1	Protein Isoforms (Isoforms)IBA 06/2002
1	Carbon MonoxideIBA 05/2002

Therapy/Procedure

2	Transplantation (Transplant Recipients) 12/2005 - 11/2004
2	Transplants (Transplant) 04/2003 - 04/2002
1	Deep Brain Stimulation 03/2004