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E J Topol Selected Research

Unstable Angina

12/2001Attenuation of rebound ischemia after discontinuation of heparin therapy by glycoprotein IIb/IIIa inhibition with eptifibatide in patients with acute coronary syndromes: observations from the platelet IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial.
12/2001Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty Study.
8/2001Risk of cardiovascular events associated with selective COX-2 inhibitors.
3/2001Variation in patient management and outcomes for acute coronary syndromes in Latin America and North America: results from the Platelet IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial.
3/2001Prognostic importance of concomitant heparin with eptifibatide in acute coronary syndromes. PURSUIT Investigators. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy.
2/2001Therapeutic value of eptifibatide at community hospitals transferring patients to tertiary referral centers early after admission for acute coronary syndromes. PURSUIT Investigators.
12/2000Enhanced efficacy of eptifibatide administration in patients with acute coronary syndrome requiring in-hospital coronary artery bypass grafting. PURSUIT Investigators.
11/2000The future of antiplatelet therapy: optimizing management in patients with acute coronary syndrome.
9/2000Management of patients with acute coronary syndromes in the United States by platelet glycoprotein IIb/IIIa inhibition. Insights from the platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial.
9/2000Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease.The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) Trial Investigators.
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E J Topol Research Topics

Disease

51Myocardial Infarction
01/2009 - 01/2000
34Acute Coronary Syndrome
02/2004 - 01/2000
18Unstable Angina
12/2001 - 01/2000
16Hemorrhage
12/2001 - 04/2000
11Infarction
12/2001 - 03/2000
9Coronary Artery Disease (Coronary Atherosclerosis)
06/2003 - 03/2000
8Stroke (Strokes)
03/2002 - 01/2000
6Thrombosis (Thrombus)
03/2002 - 03/2001
5Atherosclerosis
01/2006 - 06/2000
5Ischemia
12/2001 - 07/2000
5Inflammation
08/2001 - 11/2000
4Cardiovascular Diseases (Cardiovascular Disease)
03/2002 - 08/2000
4Thrombocytopenia (Thrombopenia)
06/2001 - 07/2000
4Pathologic Constriction (Stenosis)
03/2001 - 03/2000
3Transient Ischemic Attack
12/2001 - 06/2000
3Myocardial Ischemia (Ischemic Heart Diseases)
11/2001 - 10/2000
3Diabetes Mellitus
08/2001 - 03/2000
3Shock
09/2000 - 01/2000
3Cardiogenic Shock
09/2000 - 01/2000
2Vascular Diseases (Vascular Disease)
01/2006 - 06/2000
2Peripheral Arterial Disease
01/2006 - 07/2000
2Coronary Disease (Coronary Heart Disease)
05/2004 - 06/2002
2Heart Failure
10/2000 - 06/2000
2Chest Pain (Chest Pains)
09/2000 - 03/2000
1Atrial Fibrillation
10/2002
1Intracranial Hemorrhages (Intracranial Hemorrhage)
12/2001
1Atherosclerotic Plaque (Atheroma)
11/2001
1Arthritis (Polyarthritis)
08/2001
1Pain (Aches)
08/2001
1Cardiac Sudden Death (Sudden Cardiac Arrest)
08/2001
1Liver Diseases (Liver Disease)
08/2001
1Hyperplasia
08/2001
1Left Ventricular Dysfunction
10/2000
1Infection
10/2000

Drug/Important Bio-Agent (IBA)

37Glycoproteins (Glycoprotein)IBA
10/2003 - 01/2000
19eptifibatide (Integrilin)FDA Link
02/2002 - 01/2000
18abciximab (ReoPro)FDA Link
07/2001 - 03/2000
11Heparin (Liquaemin)FDA LinkGeneric
08/2002 - 04/2000
8Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
08/2001 - 01/2000
8Tissue Plasminogen Activator (Alteplase)FDA Link
04/2001 - 01/2000
7glucuronyl glucosamine glycan sulfate (Vessel)IBA
06/2001 - 03/2000
7StreptokinaseFDA Link
04/2001 - 03/2000
6MB Form Creatine KinaseIBA
02/2004 - 01/2000
6Platelet Membrane Glycoprotein IIbIBA
03/2002 - 01/2000
4clopidogrel (Plavix)FDA Link
01/2006 - 06/2000
4HirudinsIBA
08/2002 - 11/2000
3ThrombinFDA Link
08/2002 - 01/2000
3C-Reactive ProteinIBA
08/2001 - 11/2000
3reteplaseFDA Link
06/2001 - 10/2000
2Creatine Kinase (Creatine Phosphokinase)IBA
02/2004 - 08/2001
2thienopyridineIBA
12/2001 - 06/2000
2Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
08/2001 - 09/2000
2paragonIBA
07/2001 - 06/2001
2tirofiban (Aggrastat)FDA Link
06/2001 - 04/2000
2Ticlopidine (Ticlid)FDA LinkGeneric
03/2001 - 06/2000
2lotrafibanIBA
08/2000 - 06/2000
2Biological Markers (Surrogate Marker)IBA
06/2000 - 03/2000
14,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)IBA
05/2004
1Complement System Proteins (Complement)IBA
05/2004
1Apolipoproteins E (ApoE)IBA
05/2004
1high density lipoprotein receptorsIBA
06/2003
1LipidsIBA
06/2003
1Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
10/2002
1bivalirudin (Angiomax)FDA Link
12/2001
1ThrombospondinsIBA
11/2001
1thrombospondin 4IBA
11/2001
1Peroxidase (Myeloperoxidase)IBA
11/2001
1Lipoproteins (Lipoprotein)IBA
11/2001
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
08/2001
1Naproxen (Naprosyn)FDA LinkGeneric
08/2001
1Aligeron (AS 2)IBA
08/2001
1rofecoxib (Vioxx)FDA Link
08/2001
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
08/2001
1celecoxib (Celebrex)FDA Link
08/2001
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
08/2001
1Streptozocin (Streptozotocin)FDA Link
08/2001
1Phenobarbital (Luminal)FDA Link
08/2001
1P-SelectinIBA
08/2001
1Immunoglobulins (Immunoglobulin)IBA
08/2001
1Thromboplastin (Tissue Factor)IBA
07/2001
1Troponin T (T, Troponin)IBA
06/2001
1Trinitrotoluene (TNT)IBA
06/2001
1Plasminogen Activators (Plasminogen Activator)IBA
06/2001
1Lipid AIBA
04/2001
1ORALIT (ORS)IBA
01/2001
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
10/2000
1NitratesIBA
10/2000
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
10/2000
1CalciumIBA
10/2000

Therapy/Procedure

9Thrombolytic Therapy
01/2009 - 01/2000
5Angioplasty (Angioplasty, Transluminal)
12/2001 - 03/2000
3Stents
12/2001 - 07/2000
3Coronary Artery Bypass (Coronary Artery Bypass Surgery)
03/2001 - 06/2000
3Transplants (Transplant)
03/2001 - 03/2000
2Balloon Angioplasty
07/2000 - 05/2000
2Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
07/2000 - 03/2000
1Length of Stay
01/2003
1Electric Countershock (Cardioversion)
10/2002
1Aftercare (After-Treatment)
03/2001
1Myocardial Revascularization
11/2000