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Robin L Thurmond Selected Research

Histamine (Histamine Dihydrochloride)

9/2015Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
1/2015The histamine H4 receptor: from orphan to the clinic.
1/2015Antihistamines and itch.
11/2014Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment.
7/2014The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.
6/2014Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.
3/2014Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
3/2014The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
7/2012Histamine down-regulates IL-27 production in antigen-presenting cells.
1/2012Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system.
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Robin L Thurmond Research Topics

Disease

16Inflammation
09/2015 - 04/2004
10Asthma (Bronchial Asthma)
09/2015 - 11/2004
8Pruritus (Itching)
02/2015 - 01/2007
6Hypersensitivity (Allergy)
09/2015 - 01/2004
4Atopic Dermatitis (Atopic Eczema)
09/2015 - 04/2010
3Autoimmune Diseases (Autoimmune Disease)
01/2010 - 01/2004
2Rheumatoid Arthritis
10/2015 - 09/2015
2Immune System Diseases (Immune Disorders)
11/2014 - 03/2007
2Colitis
03/2014 - 10/2005
2Experimental Arthritis
03/2014 - 12/2004
2Arthritis (Polyarthritis)
03/2014 - 05/2005
1Rhinitis
01/2015
1Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
01/2015
1Urticaria (Hives)
01/2015
1Fibrosis (Cirrhosis)
11/2014
1Pneumonia (Pneumonitis)
11/2014
1Pulmonary Fibrosis (Hamman Rich Syndrome)
11/2014
1Myeloid Leukemia (Leukemia, Myelocytic)
09/2014
1Ischemia
06/2014
1Dermatitis
03/2014
1Disease Progression
03/2014
1Eczema
07/2012
1Skin Diseases
07/2012
1Psoriasis (Pustulosis Palmaris et Plantaris)
07/2012
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2012
1Multiple Sclerosis
01/2012
1Edema
04/2010
1Airway Remodeling
01/2010
1Neuralgia (Stump Neuralgia)
01/2010
1Hyperplasia
01/2010
1Nasal Polyps (Nasal Polyp)
11/2007
1Polyps
11/2007
1Necrosis
10/2005
1Atherosclerosis
05/2005
1Chronic Obstructive Pulmonary Disease (COPD)
05/2005
1Peritonitis
04/2004

Drug/Important Bio-Agent (IBA)

24Histamine (Histamine Dihydrochloride)FDA Link
09/2015 - 11/2004
6Histamine Antagonists (Antihistamines)IBA
01/2015 - 11/2004
4Histamine Receptors (Histamine Receptor)IBA
01/2015 - 11/2004
41- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA
04/2010 - 04/2004
3CollagenIBA
11/2014 - 01/2010
2Phosphotransferases (Kinase)IBA
10/2015 - 01/2010
2cathepsin SIBA
01/2010 - 05/2005
2Histamine H1 Receptors (Histamine H1 Receptor)IBA
03/2008 - 01/2008
1Antirheumatic Agents (DMARD)IBA
10/2015
1Neurotransmitter Agents (Neurotransmitter)IBA
09/2015
12-aminopyrimidineIBA
09/2015
1Immunoglobulin A (IgA)IBA
02/2015
1Histamine H2 ReceptorsIBA
01/2015
1LigandsIBA
01/2015
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2014
1Naproxen (Naprosyn)FDA LinkGeneric
11/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
11/2014
1Bleomycin (Blenoxane)FDA LinkGeneric
11/2014
1Messenger RNA (mRNA)IBA
09/2014
1Cetirizine (Zyrtec)FDA LinkGeneric
07/2014
1Protein Kinase CIBA
06/2014
1ReninIBA
06/2014
1Aldehyde DehydrogenaseIBA
06/2014
1Interleukin-17 (Interleukin 27)IBA
03/2014
1oligodendrocyte-myelin glycoproteinIBA
01/2012
1Biogenic Amines (Biogenic Amine)IBA
01/2012
1Fluorescein-5-isothiocyanate (FITC)IBA
04/2010
1Chemokine CX3CL1IBA
01/2010
1CytokinesIBA
01/2010
1Histamine H3 Receptors (Histamine H3 Receptor)IBA
11/2007
1Eosinophil Cationic ProteinIBA
11/2007
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2005
1Peroxidase (Myeloperoxidase)IBA
10/2005
1JNJ 10191584IBA
10/2005
1Complementary DNA (cDNA)IBA
12/2004
1Hyaluronic Acid (Hyaluronan)IBA
12/2004
1CD44 AntigensIBA
12/2004
1Histamine H1 AntagonistsIBA
11/2004
1ZymosanIBA
04/2004
11- (3- (4- (6- Chloro- 2,3- dihydro- 3- methyl- 2- oxo- 1H- benzimidazol- 1- yl)- 1- piperidinyl)propyl)- 4,5,6,7- tetrahydro- 5- (methylsulfonyl)- 3- (4- (trifluoromethyl)phenyl)- 1H- pyrazolo(4,3- c)pyridineIBA
01/2004

Therapy/Procedure

2Therapeutics
01/2015 - 01/2010
1Drug Therapy (Chemotherapy)
10/2015