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Shibu Thomas Selected Research

Calcitonin (Calcitonin, Eel)

1/2016A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells.
3/2009Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis.
1/2009Cadherin switching and activation of beta-catenin signaling underlie proinvasive actions of calcitonin-calcitonin receptor axis in prostate cancer.
12/2008Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways.
1/2007Calcitonin receptor-stimulated migration of prostate cancer cells is mediated by urokinase receptor-integrin signaling.
8/2006Calcitonin increases tumorigenicity of prostate cancer cells: evidence for the role of protein kinase A and urokinase-type plasminogen receptor.
6/2006Calcitonin stimulates the secretion of urokinase-type plasminogen activator from prostate cancer cells: its possible implications on tumor cell invasion.
11/2005Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action.
11/2005Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway.
9/2005Calcitonin stimulates multiple stages of angiogenesis by directly acting on endothelial cells.

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Shibu Thomas Research Topics

Disease

17Neoplasms (Cancer)
01/2016 - 09/2005
11Prostatic Neoplasms (Prostate Cancer)
01/2016 - 11/2005
5Neoplasm Metastasis (Metastasis)
12/2012 - 12/2008
4Urinary Bladder Neoplasms (Bladder Cancer)
12/2012 - 02/2011
1Rare Diseases (Rare Disease)
05/2013
1Carcinoma (Carcinomatosis)
12/2012
1Anoxia (Hypoxia)
11/2012
1Urologic Neoplasms (Urological Cancer)
07/2011

Drug/Important Bio-Agent (IBA)

10Calcitonin (Calcitonin, Eel)FDA LinkGeneric
01/2016 - 09/2005
6Messenger RNA (mRNA)IBA
07/2011 - 11/2005
5Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
01/2009 - 06/2006
4Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
01/2009 - 11/2005
3Calcitonin Receptors (Calcitonin Receptor)IBA
01/2009 - 01/2007
2NeuropeptidesIBA
01/2016 - 09/2005
2Phosphotransferases (Kinase)IBA
01/2016 - 02/2011
2Proteins (Proteins, Gene)IBA
01/2013 - 11/2005
2Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA
12/2012 - 06/2011
2Transcription Factors (Transcription Factor)IBA
11/2012 - 07/2011
2Membrane Proteins (Integral Membrane Proteins)IBA
11/2012 - 01/2009
2Small Interfering RNA (siRNA)IBA
11/2012 - 06/2011
2beta CateninIBA
03/2009 - 01/2009
2Carbon MonoxideIBA
12/2008 - 11/2005
1Idiopathic pulmonary hypertensionIBA
05/2013
1Androgen Antagonists (Antiandrogens)IBA
12/2012
1Androgen Receptors (Androgen Receptor)IBA
12/2012
1GossypolIBA
11/2012
1Protein Isoforms (Isoforms)IBA
07/2011
1Indicators and Reagents (Reagents)IBA
07/2011
1Complementary DNA (cDNA)IBA
06/2011
1Caveolin 1IBA
02/2011
1RNA (Ribonucleic Acid)IBA
02/2011
1VimentinIBA
01/2009
1Matrix MetalloproteinasesIBA
01/2009
1probasinIBA
12/2008
1Catalytic RNA (Ribozymes)IBA
12/2008
1matrigelIBA
03/2008
1Dihydrotachysterol (AT 10)IBA
03/2008
1Proliferating Cell Nuclear Antigen (PCNA)IBA
12/2007
1PlasminogenIBA
08/2006
1CalciumIBA
11/2005
1Adenylate Cyclase (Adenylyl Cyclase)IBA
11/2005
1Calcitonin Receptor-Like ProteinIBA
09/2005

Therapy/Procedure

2Drug Therapy (Chemotherapy)
01/2013 - 11/2005
2Cystectomy
07/2011 - 02/2011